Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database.

IF 3.2 3区医学 Q2 PHYSIOLOGY

Frontiers in Physiology Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI:10.3389/fphys.2025.1548690

Zhili Zhao, Yan Liang

{"title":"Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database.","authors":"Zhili Zhao, Yan Liang","doi":"10.3389/fphys.2025.1548690","DOIUrl":null,"url":null,"abstract":"Objective: To investigate the association between triglyceride-glucose (TyG) index and phenotypic age acceleration (PhenoAgeAccel), given the emerging importance of biological aging as a health determinant and the role of insulin resistance in aging-related processes.Methods: This cross-sectional study analyzed data from 13,291 adults aged ≥20 years in the National Health and Nutrition Examination Survey (1999-2010). The TyG index served as the exposure variable, calculated from fasting triglycerides and glucose levels. PhenoAgeAccel, derived from clinical biomarkers, was the outcome variable. Analyses adjusted for demographic, socioeconomic, and health-related covariates.Results: A significant non-linear relationship was observed between TyG index and PhenoAgeAccel, with an inflection point at 9.60. In the fully adjusted model, each unit increase in TyG index was associated with 2.21 years increase in PhenoAgeAccel (95% CI: 1.99, 2.43). The association was stronger above the inflection point (β = 8.21, 95% CI: 7.59, 8.82) compared to below it (β = 0.56, 95% CI: 0.29, 0.83).Conclusion: Higher TyG index levels are significantly associated with accelerated biological aging, particularly above a threshold of 9.60. These findings suggest the importance of metabolic health in biological aging processes and potential interventional strategies.","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1548690"},"PeriodicalIF":3.2000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078276/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fphys.2025.1548690","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To investigate the association between triglyceride-glucose (TyG) index and phenotypic age acceleration (PhenoAgeAccel), given the emerging importance of biological aging as a health determinant and the role of insulin resistance in aging-related processes.

Methods: This cross-sectional study analyzed data from 13,291 adults aged ≥20 years in the National Health and Nutrition Examination Survey (1999-2010). The TyG index served as the exposure variable, calculated from fasting triglycerides and glucose levels. PhenoAgeAccel, derived from clinical biomarkers, was the outcome variable. Analyses adjusted for demographic, socioeconomic, and health-related covariates.

Results: A significant non-linear relationship was observed between TyG index and PhenoAgeAccel, with an inflection point at 9.60. In the fully adjusted model, each unit increase in TyG index was associated with 2.21 years increase in PhenoAgeAccel (95% CI: 1.99, 2.43). The association was stronger above the inflection point (β = 8.21, 95% CI: 7.59, 8.82) compared to below it (β = 0.56, 95% CI: 0.29, 0.83).

Conclusion: Higher TyG index levels are significantly associated with accelerated biological aging, particularly above a threshold of 9.60. These findings suggest the importance of metabolic health in biological aging processes and potential interventional strategies.

查看原文本刊更多论文

甘油三酯-葡萄糖指数与表型年龄加速之间的关系：基于NHANES数据库的横断面研究。

考虑到生物衰老作为健康决定因素的重要性以及胰岛素抵抗在衰老相关过程中的作用，研究甘油三酯-葡萄糖（TyG）指数与表型年龄加速（PhenoAgeAccel）之间的关系。方法：本横断面研究分析了1999-2010年全国健康与营养调查中13291名年龄≥20岁的成年人的数据。TyG指数作为暴露变量，根据空腹甘油三酯和葡萄糖水平计算。来自临床生物标志物的PhenoAgeAccel是结果变量。分析调整了人口统计学、社会经济和健康相关协变量。结果：TyG指数与PhenoAgeAccel呈显著的非线性关系，拐点为9.60。在完全调整模型中，TyG指数每增加一个单位与表型加速增加2.21年相关（95% CI: 1.99, 2.43）。与拐点以下（β = 0.56, 95% CI: 0.29, 0.83）相比，拐点以上的相关性更强（β = 8.21, 95% CI: 7.59, 8.82）。结论：较高的TyG指数水平与生物老化加速显著相关，特别是超过9.60的阈值。这些发现提示了代谢健康在生物衰老过程中的重要性和潜在的干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Physiology PHYSIOLOGY-

CiteScore

6.50

自引率

5.00%

发文量

2608

审稿时长

14 weeks

期刊介绍： Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.