Predictive value of systemic inflammatory index (SII) for the time to negative nucleic acid conversion in patients with mild COVID-19 by the omicron wave.
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引用次数: 0
Abstract
Objective: Inflammatory indices are pivotal markers in gaging the harm of the COVID-19 trajectory. The definitive impact of inflammatory indices on forecasting the period required for a negative shift in nucleic acid status during the Omicron wave remains ambiguous. This research endeavors to delineate the relationship between the Systemic Inflammatory Index (SII) and the timeline for conversion to negative nucleic acid status in Omicron variant-infected patients, and to scrutinize the prognostic validity of SII for such conversion.
Methods: Adult patients hospitalized at the Shanghai Public Health Clinical Center with mild cases attributed to the Omicron variant were studied from March to December 2022. They were stratified into early-conversion (with mild cases attributed to (>10 days) groups). Analyzing patient information, clinical traits, and laboratory results, we divided patients into two groups. We used logistic regression to find the link between SII and virus test timing and built ROC curves to measure predictive value via AUC.
Results: A total of 2,603 patients were enrolled. Univariate analysis found big differences in pulse rates, respiratory rates, prealbumin levels, HS-CRP levels, IL-6 levels, SII, and PNI (p < 0.05) between the groups. Adjusting for confounders, logistic regression revealed that the highest SII group had a 1.46 greater risk of not clearing a 10-day PCR test than the lowest group (OR = 1.46; 95% CI, 1.173-1.817, p = 0.001). Each one-unit rise in SII raised the risk of 10-day PCR failure by 0.1% (p < 0.0001). The ROC curve showed SII's AUC as 0.603 (95% CI: 0.576-0.630), predicting virus test turn-around with a cut-off of 920.5, 61.9% specificity, and 52.5% sensitivity. Compared to other indicators such as IL-6 and HS-CRP, SII exhibited the highest AUC value and specificity.
Conclusion: In mild cases caused by the Omicron wave, there was a discernible link between the SII and the period leading to a negative nucleic acid test outcome, with higher SII values indicating an increased risk of prolonged conversion time. SII might help guide treatment better than other indicators by predicting disease course.
期刊介绍:
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
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- addressing the grand health challenges around the world