Polypharmacy on first admission to hospital for people with heart failure: baseline findings from the PULSE cohort.

IF 4.8 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Janine Beezer, Andrew L Clark, Adam Todd, Andrew Kingston, John Casement, Lucy Pages, Andrew Husband
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引用次数: 0

Abstract

Aim: To define and characterise polypharmacy in people with heart failure.

Methods: The PULSE dataset is a bespoke single centre, retrospective, longitudinal, observational cohort database of patients hospitalised for heart failure, capturing data from the first heart failure admission through to death or end of data collection, including all subsequent admissions. First admission with heart failure was used to define baseline polypharmacy.

Results: There were 660 patients included in the dataset, 55.6% male, mean age 76.1 (± SD12.3). Median number of medications on admission was 9 and on discharge 10 (25th-75th centile 7-12). Polypharmacy prevalence was 87.3% on admission, increasing at discharge to 95.1% (p<0.001). Mean medication complexity index score increased from 28.5 (±SD 14.9) at admission to 31.8 (± 14.1) at discharge; (p<0.001). Number of medications on admission increased with increasing age (p<0.001), higher Charlson Comorbidity Index (p<0.001), numerically more comorbidities (p<0.001), higher clinical frailty scale (p<0.001), longer length of stay (p=0.03), worse New York Heart Association class of symptoms (p=0.04) and a diagnosis of heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction (p=0.002). Cardiovascular medications contributed 50% of medications. Prescribing of heart failure medications reduced with increased polypharmacy.

Conclusion: Polypharmacy is common on first admission to hospital for people with heart failure. More medications at admission is associated with increasing age, co-morbidity, and frailty. People with polypharmacy are more likely to have a heart failure with preserved ejection fraction diagnosis, have worse symptoms and a longer hospital stay.

心力衰竭患者首次入院时的多药治疗:PULSE队列的基线结果
目的:定义和描述心力衰竭患者的多药治疗。方法:PULSE数据集是一个定制的单中心、回顾性、纵向、观察性队列数据库,涵盖心力衰竭住院患者,从首次心力衰竭入院到死亡或数据收集结束,包括所有后续入院。首次入院的心力衰竭被用来定义基线多重用药。结果:纳入数据集的患者660例,男性55.6%,平均年龄76.1(±SD12.3)。入院时药物的中位数为9,出院时为10(25 -75百分位7-12)。入院时多药使用率为87.3%,出院时增加至95.1%。结论:心力衰竭患者首次入院时多药较为常见。入院时服用更多药物与年龄增加、合并症和虚弱有关。多药患者更有可能有保留射血分数诊断的心力衰竭,症状更严重,住院时间更长。
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来源期刊
CiteScore
9.40
自引率
3.80%
发文量
76
期刊介绍: European Heart Journal - Quality of Care & Clinical Outcomes is an English language, peer-reviewed journal dedicated to publishing cardiovascular outcomes research. It serves as an official journal of the European Society of Cardiology and maintains a close alliance with the European Heart Health Institute. The journal disseminates original research and topical reviews contributed by health scientists globally, with a focus on the quality of care and its impact on cardiovascular outcomes at the hospital, national, and international levels. It provides a platform for presenting the most outstanding cardiovascular outcomes research to influence cardiovascular public health policy on a global scale. Additionally, the journal aims to motivate young investigators and foster the growth of the outcomes research community.
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