Antianxiety effects of dexmedetomidine: systematic review and meta-analysis.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-05-15 DOI:10.1007/s00406-025-02017-9

Teng Gao, Xiaoxing Liu, Siyu Liu, Fanglin Liu, Yuchen Zhou, Shaoheng Wang, Na Zeng, Yanping Bao, Yuefu Wang, Lin Lu

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引用次数: 0

Abstract

Background: Despite numerous studies of the anxiolytic effects of dexmedetomidine compared with those of other drugs or saline, the results have been inconsistent. Here we report a systematic review and meta-analysis to comprehensively evaluate the evidence of the anxiolytic effects of dexmedetomidine.

Methods: This research has been registered in the International Prospective Register of Systematic Reviews. The PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov database were searched for clinical trials that compared the anxiolytic effects of dexmedetomidine with those of a control group with valid anxiety scores from inception to December 29, 2024.

Results: Overall, this systematic review and meta-analysis included 25 clinical studies with 2159 participants who underwent surgery. The primary outcome revealed that patients who were treated with dexmedetomidine had significantly lower anxiety scores than others did overall (MD = - 1.73, 95% CI = [ - 2.33, - 1.13], p < 0.00001, I² = 86.5%). Dexmedetomidine was found to be more effective than benzodiazepines in relieving anxiety (MD = - 1.34, 95% CI = [ - 2.08, - 0.60], p = 0.0004, I² = 83.3%). The secondary outcomes revealed no significant differences in satisfaction, pain level, sedation scores or the risk of postoperative nausea and vomiting between patients who were treated with dexmedetomidine and controls. However, the occurrence of bradycardia was more common in the dexmedetomidine groups.

Conclusions: Overall, this meta-analysis provided evidence of the potential of dexmedetomidine for relieving anxiety among patients who undergo surgery, with superior antianxiety effects compared with those of benzodiazepines.

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右美托咪定的抗焦虑作用：系统回顾和荟萃分析。

背景：尽管有许多关于右美托咪定与其他药物或生理盐水的抗焦虑作用的研究，但结果并不一致。在这里，我们报告了一项系统回顾和荟萃分析，以全面评估右美托咪定抗焦虑作用的证据。方法：本研究已在国际前瞻性系统评价注册。我们检索了PubMed、Embase、Cochrane图书馆、Web of Science和ClinicalTrials.gov数据库，寻找从开始到2024年12月29日，右美托咪定与具有有效焦虑评分的对照组的抗焦虑效果的临床试验。结果：总体而言，本系统综述和荟萃分析包括25项临床研究，2159名接受手术的参与者。主要结局显示，接受右美托咪定治疗的患者总体焦虑评分明显低于其他患者（MD = - 1.73, 95% CI = [- 2.33, - 1.13], p 2 = 86.5%）。右美托咪定在缓解焦虑方面优于苯二氮卓类药物（MD = - 1.34, 95% CI = [- 2.08, - 0.60], p = 0.0004, I2 = 83.3%）。次要结局显示，在满意度、疼痛水平、镇静评分或术后恶心呕吐风险方面，右美托咪定组与对照组无显著差异。然而，右美托咪定组发生心动过缓更为常见。结论：总的来说，这项荟萃分析提供了右美托咪定缓解手术患者焦虑的潜力的证据，与苯二氮卓类药物相比，右美托咪定具有更好的抗焦虑效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.