In the `prophylaxis era´ people with hemophilia still need major orthopedic surgery.

IF 2.3 4区医学 Q2 HEMATOLOGY

Expert Review of Hematology Pub Date : 2025-05-18 DOI:10.1080/17474086.2025.2508506

Emerito Carlos Rodriguez-Merchan

{"title":"In the `prophylaxis era´ people with hemophilia still need major orthopedic surgery.","authors":"Emerito Carlos Rodriguez-Merchan","doi":"10.1080/17474086.2025.2508506","DOIUrl":null,"url":null,"abstract":"Introduction: A non-negligible percentage of people with hemophilia (PWH) eventually develop hemophilic arthropathy in what we might call the 'prophylaxis era'.Areas covered: Due to hemophilic arthropathy, some of the patients suffering from it will eventually require major orthopedic surgery when conservative treatment has failed. The purpose of this article has been to analyze the articles published in PubMed during the period 2020-2025, in order to detect what type of major orthopedic surgery interventions are performed in PWH during the 'prophylaxis era'. On 22 April 202522 April 2025, using 'hemophilia orthopedic surgery' from 1 January 2020 to 22 April 2025 as keywords, 373 articles were found in PubMed. Of these, 50 were analyzed because they were directly related to the title of this article (inclusion criterion). The remaining 323 were excluded because they were not directly related to the title of this article.Expert opinion: Although great progress has been made in prophylaxis therapy in PWH, some patients still suffer from severe painful and disabling hemophilic arthropathy requiring major orthopedic surgery. This suggests that there is still much room for improvement in prophylaxis therapy in PWH. Multidisciplinary teams treating PWH should redouble their efforts to eliminate hemophilic arthropathy.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"1-7"},"PeriodicalIF":2.3000,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17474086.2025.2508506","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: A non-negligible percentage of people with hemophilia (PWH) eventually develop hemophilic arthropathy in what we might call the 'prophylaxis era'.

Areas covered: Due to hemophilic arthropathy, some of the patients suffering from it will eventually require major orthopedic surgery when conservative treatment has failed. The purpose of this article has been to analyze the articles published in PubMed during the period 2020-2025, in order to detect what type of major orthopedic surgery interventions are performed in PWH during the 'prophylaxis era'. On 22 April 202522 April 2025, using 'hemophilia orthopedic surgery' from 1 January 2020 to 22 April 2025 as keywords, 373 articles were found in PubMed. Of these, 50 were analyzed because they were directly related to the title of this article (inclusion criterion). The remaining 323 were excluded because they were not directly related to the title of this article.

Expert opinion: Although great progress has been made in prophylaxis therapy in PWH, some patients still suffer from severe painful and disabling hemophilic arthropathy requiring major orthopedic surgery. This suggests that there is still much room for improvement in prophylaxis therapy in PWH. Multidisciplinary teams treating PWH should redouble their efforts to eliminate hemophilic arthropathy.

查看原文本刊更多论文

在“预防时代”，血友病患者仍然需要进行大型骨科手术。

在我们所谓的“预防时代”，血友病（PWH）患者最终发展为血友病关节病的不可忽视的百分比。涉及领域：由于血友病关节病，一些患者在保守治疗失败后最终需要进行大的骨科手术。本文的目的是分析2020-2025年期间发表在PubMed上的文章，以检测在“预防时代”PWH中进行了哪些类型的主要骨科手术干预。2025年4月22日，以“血友病骨科手术”从2020年1月1日至2025年4月22日为关键词，在PubMed中发现373篇文章。其中，有50篇因为与本文标题直接相关（纳入标准）而被分析。其余323人因与本文标题无直接关系而被排除。专家意见：虽然预防治疗在PWH方面取得了很大进展，但一些患者仍然患有严重的疼痛和致残的血友病关节病，需要进行大的骨科手术。这表明，预防治疗在PWH仍有很大的改进空间。治疗PWH的多学科团队应加倍努力消除血友病关节病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.