Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of Canavalia gladiata.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2025-05-09 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S519102

Huiqin Qian, Di Meng, Lu Yue, Haibo Xu, Kun Feng, Jianan Wang

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引用次数: 0

Abstract

Canavalia gladiata (C. gladiata) is a significant traditional Chinese medicine that has been used to treat hiccups, vomiting, nausea, amenorrhea, chronic dysentery, larynx arthralgia, lumbago, and inflammatory diseases in Asia for a long history. Although the chemical composition of C. gladiata has been reported, no thorough review of C. gladiata has been published. Therefore, the present study aimed to comprehensively analyze the ethnobotanical use, phytochemistry, pharmacology, and toxicity of C. gladiata. All the available information on C. gladiata was actualized by systematically searching scientific databases including Web of Science, ScienceDirect, PubMed, Google Scholar, Springer, Wiley, CNKI, CSPD, and Baidu Scholar between 1967 and up-to-date. Based on the reported information, more than 231 components have been identified in C. gladiata, including flavonoids, terpenes, steroids, organic acids, nitrogenous compounds, amino acids, proteins, etc. Crude extracts, fractions, and constituents from C. gladiata show various pharmacological activities, including antioxidant, antitumor, antimicrobial, anti-inflammatory, antiallergic, immunomodulatory, antiobesity, hepatoprotective, antidiabetic, etc. Notably, the immature seeds are poisonous. Besides, modern research reveals that C. gladiata is rich in chemical constituents and pharmacological activities, which are of great research value. However, more in-depth studies including chemical composition, pharmacological mechanism, quality standardisation, toxicology, and clinical research trials are needed for C. gladiata as a new candidate for future drug development.

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剑兰的民族植物学用途、植物化学、药理学和毒性。

剑兰（Canavalia gladiata， C. gladiata）是一种重要的中药，在亚洲被用来治疗打嗝、呕吐、恶心、闭经、慢性痢疾、喉痛、腰痛和炎症性疾病，历史悠久。虽然对剑兰的化学成分已有报道，但尚未对剑兰的化学成分进行深入的研究。因此，本研究旨在综合分析剑兰的民族植物学用途、植物化学、药理和毒性。通过对Web of Science、ScienceDirect、PubMed、谷歌Scholar、施普林格、Wiley、CNKI、CSPD、百度Scholar等数据库的系统检索，获得了1967年至今所有关于菖蒲的资料。根据文献报道，从剑兰中鉴定出了231多种化学成分，包括黄酮类、萜烯类、甾体、有机酸、氮化合物、氨基酸、蛋白质等。剑兰的粗提物、馏分和成分具有抗氧化、抗肿瘤、抗菌、抗炎、抗过敏、免疫调节、抗肥胖、保肝、抗糖尿病等药理活性。值得注意的是，未成熟的种子是有毒的。此外，现代研究表明，剑兰具有丰富的化学成分和药理活性，具有重要的研究价值。然而，剑兰作为未来药物开发的新候选物，其化学成分、药理机制、质量标准化、毒理学和临床研究试验等方面还有待进一步深入研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.