A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2025-05-10 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S519048

Weiyi Xiang, Xian Jiang, Linghong Guo

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引用次数: 0

Abstract

Purpose: Microneedles can physically penetrate the stratum corneum, creating micropores on the skin, and allowing for drug delivery through direct diffusion, injection, or other methods. As a novel drug delivery method, it possesses significant application potential. This study uses bibliometric analysis to explore the research hotspots and development trends of microneedle-mediated drug delivery.

Methods: Relevant research articles on microneedle-mediated drug delivery published between 1998 and 2024 in the Web of Science Core Collection (WoSCC) database were retrieved. Data analysis and visualization were performed using VOSviewer, CiteSpace, Scimago Graphica, and Pajek, enabling the prediction of research trends in microneedle-mediated drug delivery.

Results: In general, research on microneedle-mediated drug delivery has shown a continuous increase. China and the United States are the leading countries in this field of study. Notably, Ryan F. Donnelly (n=224) is the most prominent contributor to this field. The current core research directions include: disease treatment, enhancement of transdermal absorption performance of microneedles, vaccine delivery, and new materials and technologies for microneedle manufacturing.

Conclusion: Microneedle-mediated drug delivery, as a novel technology and method, holds significant research value and application potential. However, further strengthening of international collaboration and the clinical translation of research findings are needed.

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微针介导药物传递的文献计量学分析：趋势、热点和未来方向。

目的：微针可以物理地穿透角质层，在皮肤上形成微孔，并允许通过直接扩散、注射或其他方法给药。作为一种新型的给药方式，具有重要的应用潜力。本研究采用文献计量学分析，探讨微针介导给药的研究热点和发展趋势。方法：检索Web of Science Core Collection （WoSCC）数据库1998 ~ 2024年间发表的微针介导给药相关研究文章。使用VOSviewer、CiteSpace、Scimago Graphica和Pajek进行数据分析和可视化，预测微针介导给药的研究趋势。结果：总体而言，对微针介导给药的研究不断增加。中国和美国是这一研究领域的领先国家。值得注意的是，Ryan F. Donnelly （n=224）是该领域最杰出的贡献者。目前的核心研究方向包括：疾病治疗、微针透皮吸收性能增强、疫苗输送、微针制造新材料与新技术。结论：微针介导给药是一种新颖的技术和方法，具有重要的研究价值和应用潜力。然而，需要进一步加强国际合作和研究成果的临床转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.