Reproducibility of ¹⁸F-Sodium Fluoride Positron Emission Tomography for Assessing Microcalcification in Coronary Arterial and Thoracic Aortic Atherosclerosis: Is the Signal below the Resolution of PET?

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2025-05-14 DOI:10.1007/s11886-025-02240-9

Ondrej Fanta, Shiv Patil, Thomas Werner, Drew A Torigian, Abass Alavi

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Abstract

Purpose of review: The rising prevalence of atherosclerosis has prompted the development of novel diagnostic methods capable of identifying early-stage disease when therapeutic interventions may be most effective. ¹⁸F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) is a molecular imaging technique that can quantify subclinical microcalcification in arterial plaque. The focus of this review article is to discuss the utility of ¹⁸F-NaF PET/CT in assessing atherosclerotic disease of major susceptible blood vessels, particularly the coronary arteries and thoracic aorta.

Recent findings: ¹⁸F-NaF uptake observed on PET imaging demonstrates promising potential as a marker of atherosclerotic burden in individual coronary arteries, whole heart segmentations, and the thoracic aorta. Global versus focal assessment of ¹⁸F-NaF uptake in small arteries is a significant source of methodological heterogeneity among studies. The accuracy and reproducibility of ¹⁸F-NaF PET/CT may be improved by standardized quantification methods in light of the limited spatial resolution of PET, particularly through the use of techniques to evaluate global atherosclerotic burden.

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18f -氟化钠正电子发射断层扫描评估冠状动脉和胸主动脉粥样硬化微钙化的再现性：信号是否低于PET分辨率？

综述目的：动脉粥样硬化患病率的上升促使新的诊断方法的发展，能够识别早期疾病，此时治疗干预可能是最有效的。18f -氟化钠（NaF）正电子发射断层扫描/计算机断层扫描（PET/CT）是一种量化动脉斑块亚临床微钙化的分子成像技术。这篇综述文章的重点是讨论18F-NaF PET/CT在评估主要易感血管，特别是冠状动脉和胸主动脉动脉粥样硬化疾病中的应用。最近发现：PET成像观察到的18F-NaF摄取显示了作为单个冠状动脉、整个心脏节段和胸主动脉动脉粥样硬化负荷的标记物的潜力。小动脉中18F-NaF摄取的整体与局部评估是研究方法异质性的重要来源。鉴于PET的空间分辨率有限，标准化的定量方法可以提高18F-NaF PET/CT的准确性和重复性，特别是通过使用技术来评估整体动脉粥样硬化负荷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.