Bidirectional association between uveitis and psoriasis: a systematic review and meta-analysis.

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Experimental Medicine Pub Date : 2025-05-15 DOI:10.1007/s10238-025-01693-0

Doudou Wu, Rui Cai, Ying Pang, Jie Ma, Bailin Chen, Siran Bao, Kaili Zheng, Wenbo Jiang, Yiming Qi, Nuo Li

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引用次数: 0

Abstract

Background: In recent years, the prevalence of uveitis among patients with psoriasis has shown a noticeable upward trend. Previous studies have investigated the immunological mechanisms underlying the potential connection between psoriasis and uveitis, but systematic studies exploring their bidirectional relationship is absent. This study aims to systematically evaluate the bidirectional association between psoriasis and uveitis to provide evidence.

Methods: We thoroughly searched PubMed, Embase, and the Cochrane Library for relevant observational studies published from the inception of these databases up to Mar 11th, 2024. Our systematic review was based on priori protocol pre-registered in PROSPERO (No. CRD42024522464). Risk and bias assessments were analyzed using STATA 16.0.

Results: We analyzed the results from 7 studies involving 81,775,820 subjects. The results showed that the incidence of uveitis was higher in patients with psoriasis compared to patients without psoriasis (OR = 1.16, 95% CI: 1.11-1.21). At the same time, patients with uveitis showed heightened susceptibility to psoriasis (OR = 1.52, 95% CI: 1.34-1.70, I²: 90.6%, P < 0.01). The subgroup analysis found that uveitis affects the severity and type of psoriasis.

Conclusions: The current systematic review and meta-analysis found a bidirectional association between psoriasis and uveitis. Notably, patients with severe psoriasis and psoriasis with joint symptoms should be informed about their increased risk to developing uveitis.

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葡萄膜炎与牛皮癣的双向关联：一项系统综述和荟萃分析。

背景：近年来，银屑病患者中葡萄膜炎的患病率呈明显上升趋势。以往的研究已经探讨了银屑病和葡萄膜炎之间潜在联系的免疫学机制，但缺乏系统的研究来探讨它们之间的双向关系。本研究旨在系统评价银屑病与葡萄膜炎之间的双向关系，为银屑病与葡萄膜炎之间的双向关系提供证据。方法：我们全面检索PubMed、Embase和Cochrane图书馆，从这些数据库建立到2024年3月11日为止发表的相关观察性研究。我们的系统评价是基于在PROSPERO预注册的先验方案。CRD42024522464)。风险和偏倚评估采用STATA 16.0进行分析。结果：我们分析了7项研究的结果，涉及81,775,820名受试者。结果显示，银屑病患者葡萄膜炎的发生率高于无银屑病患者（OR = 1.16, 95% CI: 1.11-1.21）。同时，葡萄膜炎患者对银屑病的易感性增加（OR = 1.52, 95% CI: 1.34-1.70, I2: 90.6%， P）。结论：目前的系统评价和荟萃分析发现银屑病与葡萄膜炎之间存在双向关联。值得注意的是，严重牛皮癣患者和有关节症状的牛皮癣患者应该被告知他们患葡萄膜炎的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Medicine 医学-医学：研究与实验

CiteScore

4.80

自引率

2.20%

发文量

159

审稿时长

2.5 months

期刊介绍： Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.