Impact of oral conditions on salivary biochemical parameters in individuals with substance use disorder: a cross-sectional study.

IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Brazilian oral research Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI:10.1590/1807-3107bor-2025.vol39.053
Julia Arruda Batista, Bruno Wakayama, Rayara Nogueira de Freitas, Gabriela Alice Fiais, Antonio Hernandes Chaves-Neto, Tânia Adas Saliba, Artênio José Isper Garbin, Clea Adas Saliba Garbin
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Abstract

This study aimed to investigate oral conditions and their impact on salivary biochemical parameters in institutionalized individuals with and without substance use disorder. This was an epidemiological, cross-sectional, and clinical study. It included two groups, institutionalized individuals with substance use disorder (SUD group) and without substance use disorder (control group), each consisting of 60 participants. Salivary samples were analyzed for various parameters, while oral conditions were assessed using the DMFT index, community periodontal index, clinical attachment loss index, and need for prosthesis. Statistical analysis included the Mann-Whitney U test, t-tests, and correlation analysis (p ≤ 0.050). The SUD group showed a higher need for dental prostheses (p < 0.001) and more pronounced dental erosion (p < 0.001). This group also exhibited elevated DMFT indices, with significant associations in sextants with calculus (p = 0.010), periodontal pockets (p < 0.001), and attachment loss of 12 mm or more (p = 0.036). Regarding salivary parameters, the SUD group had high cortisol levels and significant correlations between uric acid and bleeding sextants (p = 0.024), salivary amylase and decayed teeth (p = 0.002), cortisol and the DMFT index (p = 0.045), and cortisol and the absence of DMFT (p = 0.042). In conclusion, individuals in the SUD group exhibited worse oral conditions than did those in the control group, suggesting a relationship between drug addiction and increased cortisol, uric acid, and salivary amylase levels.

药物使用障碍患者口腔状况对唾液生化参数的影响:一项横断面研究。
本研究旨在探讨有或无物质使用障碍的机构个体的口腔状况及其对唾液生化参数的影响。这是一项流行病学、横断面和临床研究。包括两组,有物质使用障碍的制度化个体(SUD组)和无物质使用障碍的制度化个体(对照组),每组60人。分析唾液样本的各种参数,同时使用DMFT指数、社区牙周指数、临床附着丧失指数和修复体需求评估口腔状况。统计分析采用Mann-Whitney U检验、t检验和相关分析(p≤0.050)。SUD组对修复体的需求更高(p < 0.001),牙侵蚀更明显(p < 0.001)。该组DMFT指数也升高,六分仪与牙石(p = 0.010)、牙周袋(p < 0.001)和附着体丢失12 mm或更多(p = 0.036)显著相关。在唾液参数方面,SUD组皮质醇水平较高,尿酸与出血六分仪(p = 0.024)、唾液淀粉酶与蛀牙(p = 0.002)、皮质醇与DMFT指数(p = 0.045)、皮质醇与DMFT缺失(p = 0.042)之间存在显著相关性。总之,与对照组相比,SUD组的个体表现出更差的口腔状况,这表明药物成瘾与皮质醇、尿酸和唾液淀粉酶水平升高之间存在关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
4.00%
发文量
107
审稿时长
12 weeks
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