Effect of intermittent fasting on obesity and metabolic indices in patients with metabolic syndrome: a systematic review and meta analysis.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Shengxuan Zhang, Bixuan Sun, Lei Sun, Shijian Zou, Qilan Chen
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引用次数: 0

Abstract

Objective: Dietary patterns play a vital role in the health management of individuals with metabolic syndrome. Many recent studies have shown that intermittent fasting (IF) has better effects, such as improving obesity. Nevertheless, it warrants further investigation to determine which approach is more effective in comparison to continuous energy restriction (CR), particularly when total calorie intake shows minimal variation. Consequently, it is crucial to evaluate the degree of enhancement of the two dietary patterns concerning different aspects of metabolic syndrome. This study presents a meta-analysis of randomized controlled trials (RCTs) aimed at comparing the impacts of IF and CR on obesity and glucolipid metabolism in individuals diagnosed with metabolic syndrome.

Methods: In August 2024, a thorough examination of English-language literature was performed across the PubMed, Medline, Embase, and Cochrane Library databases. The meta-analyses was performed according to the established guidelines and reported the results. Weight change, Body Mass Index (BMI) change, and triglyceride (TG) level change were designated as key assessment indicators, while blood pressure, blood glucose, hip circumference, and waist circumference served as supplementary indicators for comparative analysis.

Result: A total of nine studies involving 626 patients were analyzed, focusing on the influence of dietary patterns on obesity, cholesterol levels, and insulin resistance among individuals diagnosed with metabolic syndrome. Both dietary patterns were beneficial for patients with metabolic syndrome. However, IF was better than CRin terms of improvement in obesity over the trial period (mean -1.77, 95% CI [-3.06, -0.48]), and it was more conducive to a reduction in TG levels, which was beneficial in terms of improving insulin resistance (mean -10.16, 95% CI [-18.88, -1.45]).

Conclusion: Given its notable advantages for obesity, lipids, and insulin resistance, along with improved patient adherence, IF may be regarded as a more effective dietary approach for individuals with metabolic syndrome. Nonetheless, the long-term effectiveness still necessitates additional validation.

Prospero registration: CRD42024587335.

间歇性禁食对代谢综合征患者肥胖和代谢指标的影响:系统综述和荟萃分析
目的:饮食模式在代谢综合征患者的健康管理中发挥重要作用。最近的许多研究表明,间歇性禁食(IF)有更好的效果,比如改善肥胖。然而,需要进一步调查,以确定哪种方法比持续能量限制(CR)更有效,特别是在总卡路里摄入量变化最小的情况下。因此,评估两种饮食模式对代谢综合征不同方面的增强程度至关重要。本研究对随机对照试验(RCTs)进行了荟萃分析,旨在比较IF和CR对诊断为代谢综合征的个体肥胖和糖脂代谢的影响。方法:在2024年8月,对PubMed、Medline、Embase和Cochrane图书馆数据库中的英语文献进行了全面检查。meta分析是根据既定指南进行的,并报告了结果。体重变化、身体质量指数(BMI)变化、甘油三酯(TG)水平变化作为主要评价指标,血压、血糖、臀围、腰围作为补充指标进行对比分析。结果:共分析了涉及626例患者的9项研究,重点研究了饮食模式对代谢综合征患者肥胖、胆固醇水平和胰岛素抵抗的影响。两种饮食模式对代谢综合征患者都有益。然而,在试验期间,IF在改善肥胖方面优于CRin(平均-1.77,95% CI[-3.06, -0.48]),并且更有利于降低TG水平,这有利于改善胰岛素抵抗(平均-10.16,95% CI[-18.88, -1.45])。结论:鉴于其对肥胖、血脂和胰岛素抵抗的显著优势,以及患者依从性的提高,IF可能被视为代谢综合征患者更有效的饮食方法。尽管如此,长期有效性仍然需要额外的验证。普洛斯彼罗注册:CRD42024587335。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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