Unravelling the role of interleukin-6 in regulating dental stem cell behaviour: a scoping review.

IF 2.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

BMC Oral Health Pub Date : 2025-05-15 DOI:10.1186/s12903-025-06097-w

Itt Assoratgoon, Nunthawan Nowwarote, Suphalak Phothichailert, Waruna L Dissanayaka, Lakshman P Samaranayake, Thanaphum Osathanon

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引用次数: 0

Abstract

Background: Interleukin-6 (IL-6) functions as a pro-inflammatory and anti-inflammatory cytokine. IL-6 plays a pivotal role in a multitude of biological processes. This scoping review aimed to explore the impact of IL-6 on the biological responses of dental tissue-derived mesenchymal stem cells.

Methods: The literature databases (PubMed and Scopus) were searched utilising specific design keywords. The criteria for inclusion encompassed (1) original research investigations that examined the effect of IL-6 on dental stem cells through the introduction of exogenous IL-6, overexpression, or knockdown expression, and (2) publications authored in the English language. The articles that conformed to these criteria were subsequently compiled for comprehensive full-text analysis and data extraction.

Results: The literature search identified 323 articles, including 99 and 224 pertinent publications from the PubMed and Scopus databases, respectively. After screening, 14 publications satisfied the inclusion criteria and were subsequently selected for data extraction. The findings demonstrated that IL-6 regulates stemness maintenance, cellular proliferation, and differentiation towards osteogenic, adipogenic, chondrogenic, and neurogenic lineages in dental tissue-derived mesenchymal stem cells.

Conclusion: IL-6 modulates the biological activities of mesenchymal stem cells, particularly those derived from dental tissues. Nevertheless, the inconsistencies observed across various studies may be attributable to a range of factors, including the heterogeneity inherent in stem cell sources, the stages of differentiation, the conditions of culture, and the particularities of experimental design.

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揭示白介素-6在调节牙齿干细胞行为中的作用：范围综述。

背景：白细胞介素-6 （IL-6）是一种促炎和抗炎细胞因子。IL-6在许多生物过程中起着关键作用。本综述旨在探讨IL-6对牙组织源性间充质干细胞生物学反应的影响。方法：采用特定设计关键词对文献数据库PubMed和Scopus进行检索。纳入标准包括：(1)通过引入外源性IL-6、过表达或低表达来检查IL-6对牙齿干细胞影响的原始研究调查，以及(2)以英语撰写的出版物。随后对符合这些标准的文章进行汇编，以便进行全面的全文分析和数据提取。结果：检索到文献323篇，其中PubMed和Scopus数据库相关文献分别为99篇和224篇。筛选后，有14篇出版物符合纳入标准，随后选择进行数据提取。研究结果表明，IL-6调节牙组织源性间充质干细胞的干细胞维持、细胞增殖和向成骨、脂肪、软骨和神经源性分化。结论：IL-6可调节间充质干细胞的生物学活性，尤其是牙组织间充质干细胞。然而，在各种研究中观察到的不一致可能归因于一系列因素，包括干细胞来源固有的异质性、分化阶段、培养条件和实验设计的特殊性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Oral Health DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

6.90%

发文量

481

审稿时长

6-12 weeks

期刊介绍： BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.