Enhanced structural brain connectivity analyses using high diffusion-weighting strengths.

IF 2.7 3区 医学 Q1 ANATOMY & MORPHOLOGY
Leyao Yu, Adeen Flinker, Jelle Veraart
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引用次数: 0

Abstract

Tractography is a unique modality for the in vivo measurement of structural connectivity, crucial for understanding brain networks and neurological conditions. With increasing b-value, the diffusion-weighting signal becomes primarily sensitive to the intra-axonal signal. However, it remains unclear how tractography is affected by this observation. Here, using open-source datasets, we showed that at high b-values, DWI reduces the uncertainty in estimating fiber orientations. Specifically, we found the ratio of biologically-meaningful longer-range connections increases, accompanied with downstream impact of redistribution of connectome and network metrics. However, when going beyond b = 6000 s/mm2, the loss of SNR imposed a penalty. Lastly, we showed that the data reaches satisfactory reproducibility with b-values above 1200 s/mm2. Overall, the results suggest that using b-values above 2500 s/mm2 is essential for more accurate connectome reconstruction by reducing uncertainty in fiber orientation estimation, supporting the use of higher b-value protocols in standard diffusion MRI scans and pipelines.

使用高扩散加权强度增强结构脑连接分析。
神经束造影是体内测量结构连通性的一种独特方式,对理解脑网络和神经系统疾病至关重要。随着b值的增大,弥散加权信号主要对轴突内信号敏感。然而,目前尚不清楚这一观察结果是如何影响肌腱束造影的。在这里,使用开源数据集,我们发现在高b值时,DWI减少了估计光纤方向的不确定性。具体来说,我们发现具有生物学意义的长距离连接的比例增加,同时伴随着连接组和网络指标再分配的下游影响。然而,当超过b = 6000s /mm2时,信噪比的损失就会受到惩罚。最后,我们表明,当b值高于1200 s/mm2时,数据达到令人满意的再现性。总的来说,结果表明,通过减少光纤方向估计的不确定性,使用高于2500 s/mm2的b值对于更准确的连接体重建至关重要,支持在标准扩散MRI扫描和管道中使用更高的b值协议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain Structure & Function
Brain Structure & Function 医学-解剖学与形态学
CiteScore
6.00
自引率
6.50%
发文量
168
审稿时长
8 months
期刊介绍: Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.
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