Bio-inspired Synthesis, Characterization, and Biomedical Applications of Optimized Ceiba pentandra Silver Nanoparticles.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Trace Element Research Pub Date : 2025-05-16 DOI:10.1007/s12011-025-04652-8

Loick Pradel Kojom Foko, Joseph Hawadak, Philippe Belle Ebanda Kedi, Veena Pande, Vineeta Singh

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Abstract

Green nanotechnology can provide new avenues for drug and insecticide discovery. This study aimed at synthesizing and evaluating the potential of silver nanoparticles, using an innovative plant-driven synthesis approach, with the potential to be used as an endectocide. Optimized silver nanoparticles using Ceiba pentandra (CP-AgNPs) were evaluated for their hemotoxic and killing activities against the deadliest malaria parasite Plasmodium falciparum (Pf) and three mosquito species (Culex quinquefasciatus, Anopheles stephensi, and Aedes aegypti) of medical importance. Optimized CP-AgNPs were predominantly spheroidal, stable, polycrystalline, and coated with several phytochemical compounds, including terpenoids, alkaloids, and phenols. CP-AgNPs exhibited good hemocompatibility and high lethal activity on Pf 3D7 and RKL9 strains, with respective IC₅₀ values of 9.71 µg/mL and 15.57 µg/mL. Likewise, LC₅₀ values were < 20 µg/mL in the three mosquito species after 24-h exposure, and the CP-AgNPs were most toxic against An. stephensi (LC₅₀ = 13.48 µg/mL). Green AgNPs could be an interesting tool for discovering and developing eco-friendly and effective antimalarial drugs and insecticides.

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五角草银纳米颗粒的合成、表征及生物医学应用。

绿色纳米技术可以为药物和杀虫剂的发现提供新的途径。本研究旨在利用一种创新的植物驱动合成方法合成和评估银纳米颗粒的潜力，该纳米颗粒有可能被用作内灭剂。利用五角木（Ceiba pentandra, CP-AgNPs）优化的银纳米颗粒对致命的恶性疟原虫（Plasmodium falciparum, Pf）和三种医学上重要的蚊子（致倦库蚊、斯氏按蚊和埃及伊蚊）的血液毒性和杀伤活性进行了评估。优化后的CP-AgNPs主要是球形的、稳定的、多晶的，并且包被多种植物化合物，包括萜类、生物碱和酚类。CP-AgNPs对Pf 3D7和RKL9菌株具有良好的血液相容性和较高的致死活性，IC50值分别为9.71µg/mL和15.57µg/mL。LC50值为50 = 13.48µg/mL)。绿色AgNPs可能是发现和开发生态友好和有效的抗疟疾药物和杀虫剂的有趣工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.