Tumor heterogeneity and resistance in glioblastoma: the role of stem cells.

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-05-15 DOI:10.1007/s10495-025-02123-y

Nikita Ghosh, Debarpan Chatterjee, Aparna Datta

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Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant brain tumor, characterized by its heterogeneity and the presence of glioblastoma stem cells (GSCs). GSCs are a subpopulation of cells within the tumor that possess self-renewal and differentiation capabilities, contributing to tumor initiation, progression, and recurrence. This review explores the unique biological properties of GSCs, including their molecular markers, signalling pathways, and interactions with the tumor microenvironment. We discuss the mechanisms by which GSCs evade conventional therapies, such as enhanced DNA repair and metabolic plasticity, which complicate treatment outcomes. Furthermore, we highlight recent advancements in identifying novel biomarkers and therapeutic targets that may improve the efficacy of treatments aimed at GSCs. The potential of targeted therapies, including immunotherapy and combination strategies, is also examined to overcome the challenges posed by GSCs. Ultimately, a deeper understanding of GSC biology is essential for developing personalized treatment approaches that can enhance patient outcomes in glioblastoma.

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胶质母细胞瘤的肿瘤异质性和耐药性：干细胞的作用。

多形性胶质母细胞瘤（GBM）是最具侵袭性和治疗抗性的脑肿瘤之一，其特点是其异质性和胶质母细胞瘤干细胞（GSCs）的存在。GSCs是肿瘤内具有自我更新和分化能力的细胞亚群，有助于肿瘤的发生、进展和复发。本文综述了GSCs独特的生物学特性，包括其分子标记、信号通路以及与肿瘤微环境的相互作用。我们讨论了GSCs逃避常规治疗的机制，如增强DNA修复和代谢可塑性，这使治疗结果复杂化。此外，我们强调了在识别新的生物标志物和治疗靶点方面的最新进展，这些生物标志物和治疗靶点可能会提高针对GSCs的治疗效果。靶向治疗的潜力，包括免疫治疗和联合策略，也被审查，以克服GSCs带来的挑战。最终，更深入地了解胶质母细胞瘤生物学对于开发个性化治疗方法至关重要，可以提高胶质母细胞瘤患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.