Laser prophylaxis for retinal detachment in Stickler syndrome: A systematic review and meta-analysis

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2025-05-15 DOI:10.1111/aos.17509

David A. Camp, Saaquib R. Bakhsh, Ali Torkashvand, Nathan R. Jensen, Ameay V. Naravane, Peter J. Belin, Polly A. Quiram, Tsveta Ivanova, Thomas J. Wubben, Cagri G. Besirli, Brenda L. Bohnsack, Michael J. Shapiro, Michael P. Blair, Amir R. Hajrasouliha

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引用次数: 0

Abstract

Purpose

To evaluate the effectiveness of laser prophylaxis in preventing retinal detachment (RD) in patients with Stickler syndrome.

Methods

A literature search was performed to identify studies that compared RD rates between eyes that received laser prophylaxis and eyes that received no laser prophylaxis in patients with Stickler syndrome. Data sets from the included studies were pooled and analysed. Individual eyes that presented with RD and eyes without RD with <6 months of follow-up were excluded. The primary outcome was the rate of RD. The study was conducted in accordance with the PRISMA guideline 2020 for systematic reviews.

Results

There were 6 articles included in the meta-analysis, including 400 eyes of 225 patients. RD rate was 6.6% (19 of 289) in eyes with laser compared to 36.0% (40 of 111) in eyes with no laser (p < 0.00001, chi-square) with a mean follow-up interval of 6.3 years for eyes with laser and 4.0 years for eyes with no laser. The pooled risk ratio for retinal detachment after laser prophylaxis was 0.23 (95% CI: 0.13–0.41).

Conclusion

Prophylactic laser therapy was associated with a significantly lower risk of RD in patients with Stickler syndrome compared to no laser prophylaxis.

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激光预防Stickler综合征视网膜脱离：系统回顾和荟萃分析。

目的：评价激光预防术预防Stickler综合征视网膜脱离（RD）的效果。方法：进行文献检索，以确定比较Stickler综合征患者接受激光预防和未接受激光预防的眼睛之间RD率的研究。对纳入研究的数据集进行汇总和分析。出现RD的个体眼睛和没有RD的眼睛的结果：meta分析纳入了6篇文章，包括225名患者的400只眼睛。接受激光治疗的患者RD发生率为6.6%(19 / 289)，而未接受激光治疗的患者RD发生率为36.0%（40 / 111）。(p)结论：预防性激光治疗与未接受激光治疗的Stickler综合征患者RD风险显著降低相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.