Development of a method for rapid determination of 98 PPCPs in drinking water by SPE-UPLC-MS/MS†

IF 2.7 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analytical Methods Pub Date : 2025-04-29 DOI:10.1039/D5AY00307E

Rongting Zhuo, Rong Bao, Yanzhong Fan, Qi Lin and Yan Yang

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Abstract

Residues of pharmaceuticals and personal care products (PPCPs) in drinking water pose significant public health risks. To assess these residues in water, this study developed a solid-phase extraction combined with ultra-performance liquid chromatography-tandem mass spectrometry method (SPE-UPLC-MS/MS) for the simultaneous quantitative determination of 98 PPCP residues in drinking water. By optimizing the pretreatment method and analysis conditions, the method exhibits excellent linearity, with all PPCPs showing correlation coefficients (R²) greater than 0.99 within the concentration range of 0–100 μg L⁻¹. Recovery rates ranged from 60.7% to 119.0%, and the relative standard deviations (RSDs) were below 20%. The limits of detection (LODs) were between 0.034 and 4.001 ng L⁻¹. Residues such as amisulpride and 1,7-dimethylxanthine were detected in water samples. This method is simple, sensitive, and suitable for high-throughput detection of trace PPCPs in drinking water, providing reliable technical support for water quality monitoring.

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SPE-UPLC-MS/MS快速测定饮用水中98种PPCPs方法的建立。

饮用水中的药物和个人护理产品残留物构成重大的公共卫生风险。为了评估水中PPCP的残留，本研究建立了固相萃取联合超高效液相色谱-串联质谱（SPE-UPLC-MS/MS）同时定量测定饮用水中98种PPCP残留的方法。通过优化前处理方法和分析条件，该方法线性良好，在0 ~ 100 μg L-1的浓度范围内，各PPCPs的相关系数（R2）均大于0.99。加样回收率为60.7% ~ 119.0%，相对标准偏差（rsd）在20%以下。检出限为0.034 ~ 4.001 ng L-1。在水样中检测到咪硫脲和1,7-二甲基黄嘌呤等残留物。该方法简便、灵敏，适用于饮用水中痕量PPCPs的高通量检测，为水质监测提供可靠的技术支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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