{"title":"A naphthalimide derivative-based fluorescent probe for selective detection of hydrogen peroxide and H<sub>2</sub>O<sub>2</sub> vapor.","authors":"Lin-E Guo, Yuqiang Zhao, Jiazhong Zhang, Ying Zhou","doi":"10.1039/d5ay00179j","DOIUrl":null,"url":null,"abstract":"<p><p>Triacetone triperoxide (TATP) is one of the most commonly used improvised explosive devices by terrorists. Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) serves as a synthetic precursor and degradation product of peroxide-based TATP. Herein, a \"turn-on\" pattern H<sub>2</sub>O<sub>2</sub>-selective naphthalimide derivative fluorescent probe was synthesized and characterized, demonstrating high selectivity and sensitivity for the detection of H<sub>2</sub>O<sub>2</sub>. The probe operates <i>via</i> a donor-excited photo-induced electron transfer (d-PET) mechanism, resulting in a 60-fold fluorescence enhancement in response to H<sub>2</sub>O<sub>2</sub>. As a result, the proposed probe can detect H<sub>2</sub>O<sub>2</sub> within a linear range of 0 to 40 μM, with a detection limit of 59.6 nM. Notably, the probe was successfully employed for the rapid detection of H<sub>2</sub>O<sub>2</sub> vapor with high sensitivity at concentrations below 10 ppb, yielding visible results to the naked eye. It has also been successfully used for cell imaging.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Methods","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5ay00179j","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Triacetone triperoxide (TATP) is one of the most commonly used improvised explosive devices by terrorists. Hydrogen peroxide (H2O2) serves as a synthetic precursor and degradation product of peroxide-based TATP. Herein, a "turn-on" pattern H2O2-selective naphthalimide derivative fluorescent probe was synthesized and characterized, demonstrating high selectivity and sensitivity for the detection of H2O2. The probe operates via a donor-excited photo-induced electron transfer (d-PET) mechanism, resulting in a 60-fold fluorescence enhancement in response to H2O2. As a result, the proposed probe can detect H2O2 within a linear range of 0 to 40 μM, with a detection limit of 59.6 nM. Notably, the probe was successfully employed for the rapid detection of H2O2 vapor with high sensitivity at concentrations below 10 ppb, yielding visible results to the naked eye. It has also been successfully used for cell imaging.
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