Ythdf2 Ablation Protects Aged Retina From RGC Dendrite Shrinking and Visual Decline.

IF 8 1区医学 Q1 CELL BIOLOGY

Aging Cell Pub Date : 2025-05-15 DOI:10.1111/acel.70107

Fugui Niu, Gaoxin Long, Jian Zhang, Jun Yu, Sheng-Jian Ji

引用次数: 0

Abstract

Aging-related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the m⁶A reader YTHDF2 is a negative regulator for dendrite development and protection of retinal ganglion cells (RGC) in mice. Here, we further show that conditional ablation of Ythdf2 protects the retina from RGC dendrite shrinking and vision loss in aged mice. Additionally, we identify Hspa12a and Islr2 as the potential YTHDF2 target mRNAs mediating these effects. Together, our results indicate that the m⁶A reader YTHDF2 regulates retinal degeneration caused by aging, which might provide important therapeutic potential for developing new treatment approaches against aging-related vision loss.

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Ythdf2消融保护衰老视网膜免受RGC树突萎缩和视力下降。

与年龄相关的视网膜变性和视力丧失已经严重影响了世界范围内的老年人。先前，我们发现m6A读取器YTHDF2是小鼠树突发育和视网膜神经节细胞（RGC）保护的负调节因子。在这里，我们进一步表明，条件消融Ythdf2可以保护老年小鼠的视网膜免受RGC树突萎缩和视力丧失。此外，我们确定Hspa12a和Islr2是介导这些作用的潜在YTHDF2靶mrna。总之，我们的研究结果表明，m6A读取器YTHDF2调节由衰老引起的视网膜变性，这可能为开发新的治疗方法提供重要的治疗潜力，以对抗衰老相关的视力丧失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology

自引率

2.60%

发文量

212

期刊介绍： Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.