Biomimetic and Biological Applications of DNA Coacervates

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-04-19 DOI:10.1002/cjoc.202401276

Yuqi Zeng, Long Zhao, Yihao Liu, Tianhuan Peng, Yifan Lyu, Quan Yuan

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引用次数: 0

Abstract

Comprehensive Summary

Recent progress in nanotechnology and synthetic biology has demonstrated the potential of DNA coacervates for biomimetic and biological applications. DNA coacervates are micron-scale, membrane-free, spherical structures formed by liquid-liquid phase separation of DNA materials. They uniquely combine the programmability of DNA with the fluidic properties of coacervates, allowing for controlled modulation of their structures, biomimetic and biological functions, and dynamic behaviors through rational sequence design. This review summarizes methods for the formation of different DNA coacervates and explores their extensive applications in biomimicry, biosensing and therapeutics. Limitations and prospects of DNA coacervates are also discussed.

Key Scientists

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DNA凝聚体的仿生及生物学应用

纳米技术和合成生物学的最新进展已经证明了DNA凝聚体在仿生和生物学应用方面的潜力。DNA凝聚体是DNA材料液-液相分离形成的微米级、无膜的球形结构。它们独特地将DNA的可编程性与凝聚体的流体特性相结合，允许通过合理的序列设计对其结构、仿生和生物功能以及动态行为进行可控调节。本文综述了不同DNA凝聚体的形成方法，并探讨了其在仿生学、生物传感和治疗等方面的广泛应用。讨论了DNA凝聚的局限性和前景。关键的科学家

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.