Anthony A. Birkbeck, Christian Chapuis, Michel Schalk
{"title":"Approaches to Commercial Sandalwood Odorants from Renewable Sources","authors":"Anthony A. Birkbeck, Christian Chapuis, Michel Schalk","doi":"10.1002/hlca.202500010","DOIUrl":null,"url":null,"abstract":"<p>The rich chemistry of East Indian Sandalwood oil has fascinated chemists for over a century. Whilst the synthesis on industrial scale of the principal odour vector (−)-(<i>Z</i>)-β-Santalol <b>2</b>, has resisted all attempts to date, many synthetic fragrant sandalwood ingredients have been discovered and manufactured on industrial scale. This precious wood is still listed as endangered and appears on the CITES red list, despite an increased number of plantations being developed. This review will focus on the interesting chemistry of <i>Santalum album</i> (<span>Linn.</span>) essential oil and the subsequent efforts by researchers to find a viable substitute for this highly appreciated oil both by investigating novel structures and using biotech approaches. The emphasis will be on the approaches to these highly appreciated odorants made from renewable resources that are currently manufactured on multi-MT scale. Lesser emphasis will be placed on close structural analogues that have not been commercially successful.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 5","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helvetica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hlca.202500010","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The rich chemistry of East Indian Sandalwood oil has fascinated chemists for over a century. Whilst the synthesis on industrial scale of the principal odour vector (−)-(Z)-β-Santalol 2, has resisted all attempts to date, many synthetic fragrant sandalwood ingredients have been discovered and manufactured on industrial scale. This precious wood is still listed as endangered and appears on the CITES red list, despite an increased number of plantations being developed. This review will focus on the interesting chemistry of Santalum album (Linn.) essential oil and the subsequent efforts by researchers to find a viable substitute for this highly appreciated oil both by investigating novel structures and using biotech approaches. The emphasis will be on the approaches to these highly appreciated odorants made from renewable resources that are currently manufactured on multi-MT scale. Lesser emphasis will be placed on close structural analogues that have not been commercially successful.
期刊介绍:
Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.