Unveiling the Spectrum of Respiratory Syncytial Virus Disease in Adults: From Community to Hospital

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-05-16 DOI:10.1111/irv.70107

Koos Korsten, Matthijs R. A. Welkers, Thijs van de Laar, Alex Wagemakers, Peter van Hengel, Peter C. Wever, Eva Kolwijck

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引用次数: 0

Abstract

Background

Respiratory syncytial virus can cause severe disease in the older adult population. Three vaccines for RSV are currently market approved but the risk of RSV-hospitalization in (older) adults from a community level remains elusive. We aimed to estimate the risk of RSV-hospitalization and characterize the patients that end up in hospital.

Methods

We manually analyzed records of adults aged ≥ 20 with RSV-infection between 2022 and 2024 in three hospitals in the Netherlands. These hospitals implemented routine RSV-testing at emergency departments. Using population-based data in combination with the in-hospital data, we estimated the population risk of RSV-hospitalization. Hospital records were analyzed to characterize the role RSV played in their course of disease.

Results

We analyzed 709 RSV cases of whom 503 (70.9%) were hospitalized. Five hundred twenty-six patients were ≥ 60, and 183 were < 60 years of age. The population RSV-hospitalization rate was 6–20 per 100.000 patients aged 20–59 years and 43–236 per 100.000 for those ≥ 60. The highest risks were observed in those with COPD (1702 per 100.000) and with congestive heart disease (2383 per 100.000). RSV caused clinically relevant infection in 88% of hospitalized cases but was only mentioned using specific ICD-codes in 4.4%. Comorbidity was prevalent (88.5%) and exacerbation of underlying disease caused of 46.3% of RSV-related hospital admissions. ICU admittance was 11.2% and in-hospital mortality was 8.1%.

Conclusion

The risk of RSV-hospitalization from the community is low but is increased substantially in those with underlying disease. RSV is often clinically relevant in hospitalized patients by causing exacerbation of underlying disease but is infrequently mentioned in specific ICD-codes.

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揭示成人呼吸道合胞病毒疾病的频谱：从社区到医院

背景呼吸道合胞病毒可在老年人中引起严重疾病。目前市场批准了三种RSV疫苗，但社区（老年人）RSV住院的风险仍然难以捉摸。我们的目的是估计rsv住院的风险，并确定最终住院的患者的特征。方法人工分析荷兰三家医院2022 - 2024年间年龄≥20岁的rsv感染成人病例。这些医院在急诊科实施了常规rsv检测。使用基于人群的数据结合住院数据，我们估计了rsv住院的人群风险。分析了医院记录，以确定RSV在他们的病程中所起的作用。结果共分析709例RSV病例，其中住院503例（70.9%）。≥60岁526例，60岁183例。20-59岁患者的rsv住院率为6-20 / 10万，≥60岁患者的rsv住院率为43-236 / 10万。COPD（每10万人中有1702人）和充血性心脏病（每10万人中有2383人）的风险最高。呼吸道合胞病毒在88%的住院病例中引起临床相关感染，但只有4.4%的病例使用特定的icd编码被提及。合并症很普遍（88.5%），46.3%的rsv相关住院患者因潜在疾病加重而入院。ICU住院率为11.2%，住院死亡率为8.1%。结论来自社区的rsv住院风险较低，但有基础疾病者住院风险明显增加。RSV通常通过引起基础疾病的恶化而与住院患者具有临床相关性，但在特定的icd代码中很少提及。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.