Prevalence of Hypertension and Blood Pressure Control in Familial Mediterranean Fever Patients

IF 2.4 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-05-15 DOI:10.1155/ijcp/9977641

Gozde Kavgaci, Haci Hasan Yeter, Muge Uzerk Kibar, Tolga Yildirim, Banu Balci Peynircioglu, Seref Rahmi Yilmaz, Yunus Erdem

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Abstract

Background and Objective: Familial Mediterranean fever (FMF) is characterized by inflammatory febrile attacks with polyserositis and is associated with an increased risk of cardiovascular disease. We aimed to determine the prevalence of hypertension (HT) in FMF patients and compare the frequency with that of the general population.

Methods: This was a retrospective cohort study. Patients diagnosed with FMF between 2000 and 2020 and participants in the PatenT 2 study were included. We used office blood pressure measurements taken with calibrated sphygmomanometers.

Results: We enrolled 528 patients with FMF and 1234 age- and gender-matched controls. The mean age of the study population was 35.48 ± 13.54, and 314 (59.5%) of the total patients were female. The prevalence of HT was lower in FMF patients compared to the control group [68 (12.9%) vs. 215 (17.4%), p = 0.02]. Patients without amyloidosis had significantly lower mean systolic blood pressure (SBP) and higher mean diastolic blood pressure (DBP) compared to the control group (113.4 ± 15.5 vs. 120.9 ± 15.94, p < 0.001, and 72.4 ± 11.03 vs. 71.07 ± 10.53, p = 0.05, respectively). Of the patients without amyloidosis, 294 (63.1%) had normal SBP and DBP, while 28 (45.2%) patients with amyloidosis and 616 (49.9%) control group participants had normal SBP and DBP. Regression analysis showed that GFR < 60 mL/min/1.73 m² and increasing age were risk factors for the development of HT.

Conclusion: The prevalence of HT, mean blood pressure, and achievement of target blood pressure are better in FMF patients than in the general population. However, blood pressure control decreases with increasing age, especially when eGFR falls below 60 mL/min/1.73 m².

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家族性地中海热患者高血压患病率及血压控制

背景和目的：家族性地中海热（FMF）的特点是伴有多浆膜炎的炎症性发热发作，并与心血管疾病的风险增加有关。我们的目的是确定FMF患者中高血压（HT）的患病率，并将其频率与一般人群进行比较。方法：回顾性队列研究。2000年至2020年间诊断为FMF的患者和专利2号研究的参与者被纳入研究对象。我们使用办公室用校准过的血压计测量血压。结果：我们招募了528名FMF患者和1234名年龄和性别匹配的对照组。研究人群平均年龄为35.48±13.54岁，女性314例（59.5%）。FMF患者的HT患病率低于对照组[68人（12.9%）对215人（17.4%），p = 0.02]。与对照组相比，无淀粉样变性患者的平均收缩压（SBP）显著降低，平均舒张压（DBP）显著升高(113.4±15.5∶120.9±15.94,p <；72.4±11.03 vs 71.07±10.53,p = 0.05)。无淀粉样变患者中收缩压和舒张压正常294例（63.1%），而淀粉样变患者和对照组分别有28例（45.2%）和616例（49.9%）收缩压和舒张压正常。回归分析显示GFR <；60 mL/min/1.73 m2和年龄增长是HT发生的危险因素。结论：FMF患者的HT患病率、平均血压、血压达标情况均优于普通人群。然而，随着年龄的增长，血压控制能力下降，特别是当eGFR低于60 mL/min/1.73 m2时。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.