First Report of Hydrolysis of Dihydrazides into Carboxylates in Mild Aqueous Conditions

IF 1.5 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Kilian Caillaud, Kilian Pouchelon, Fernande Da Cruz-Boisson, Élodie Fromentin, Agnès Crépet, Catherine Ladavière
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引用次数: 0

Abstract

The hydrolysis of dihydrazides was studied at different pH values in water at 25 °C. The resulting species were analyzed by HPLC, 1H-NMR, and MALDI-TOF mass spectrometry. Among these species, unexpected molecules bearing carboxylate moieties were detected. Based on this analysis, a 2-step hydrolysis mechanism was proposed involving the formation of cyclic and linear intermediates before the addition of a water molecule to lead to carboxylate moieties. The first step was shown to be rate-determining and catalyzed in acidic conditions. To the best of our knowledge, this study shows for the first time that the hydrolysis of some dihydrazides can spontaneously occur in mild aqueous conditions, contrary to monohydrazides which do not reveal such a hydrolysis in same conditions. This draws attention to an overlooked degradation which might need more consideration, and possibly highlights new ways of soft hydrolysis conditions.

二肼类化合物在温和水条件下水解成羧酸盐的首次报道
研究了二肼类化合物在25℃水中不同pH值下的水解反应。采用HPLC、1H-NMR和MALDI-TOF质谱分析所得物种。在这些物种中,检测到意想不到的带有羧酸基团的分子。基于这一分析,提出了一个两步水解机制,包括在加入水分子之前形成环状和线性中间体,从而导致羧酸酯部分。第一步被证明是速率决定的,并在酸性条件下催化。据我们所知,这项研究首次表明,一些二肼类化合物的水解可以在温和的水条件下自发发生,而单肼类化合物在相同的条件下不会发生这种水解。这引起了人们对可能需要更多考虑的被忽视的降解的注意,并可能突出软水解条件的新方法。
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来源期刊
Helvetica Chimica Acta
Helvetica Chimica Acta 化学-化学综合
CiteScore
3.00
自引率
0.00%
发文量
60
审稿时长
2.3 months
期刊介绍: Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.
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