FGF-7 treatment accelerates wound healing in concentration-dependent manner by regulating TGF-β1 and VEGF expression

IF 2.8 4区工程技术 Q2 POLYMER SCIENCE

Macromolecular Research Pub Date : 2025-01-09 DOI:10.1007/s13233-024-00358-3

Young-Sik Kim, Gun-Jae Jeong, Jung Soo Lee, Ju Woong Jang, Sae Hyun Kim, Heung Jae Chun, Dae Hyeok Yang

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Abstract

In this study, we report the effects of fibroblast growth factor-7 (FGF-7) concentration on wound healing, which has been less extensively studied compared to other growth factors. Assessment of the concentration-dependent effects of FGF-7 in an in vitro cell scratch assay showed that FGF-7 promoted human HaCaT keratinocyte migration into the wound area. In an in vivo animal test, local treatment with FGF-7 (up to 100 μg) resulted in no toxicity. In addition, we found that when 100 μg of FGF-7 was administered, transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), and hydroxyproline, which are all related to wound healing, were significantly upregulated, followed by accelerated wound healing. All our results demonstrated that the FGF-7 concentration affects wound healing, and a dose of 100 μg of FGF-7 exhibited the most pronounced wound healing effect.

Graphical abstract

Increased wound recovery effect according to increased FGF-7 concentration in an in vivo wound model

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FGF-7治疗通过调节TGF-β1和VEGF表达，呈浓度依赖性促进创面愈合

在这项研究中，我们报道了成纤维细胞生长因子-7 （FGF-7）浓度对伤口愈合的影响，与其他生长因子相比，这方面的研究较少。在体外细胞划伤实验中对FGF-7浓度依赖性的评估表明，FGF-7促进人HaCaT角质形成细胞向伤口区域迁移。在体内动物试验中，局部使用FGF-7（高达100 μg）治疗无毒性。此外，我们发现100 μg FGF-7可显著上调与创面愈合相关的转化生长因子-β1 （TGF-β1）、血管内皮生长因子（VEGF）和羟脯氨酸，并加速创面愈合。结果表明，FGF-7浓度影响创面愈合，100 μg剂量的FGF-7创面愈合效果最显著。在体内伤口模型中，根据FGF-7浓度的增加，伤口恢复效果增加

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.