Synthesis and antihypoxic activity of 2-amino-1-aryl-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-1H-4,5-dihydropyrrole-3-carboxylic acid derivatives

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-05-15 DOI:10.1007/s11172-025-4607-5

K. L. Gankova, S. S. Zykova, I. A. Gorbunova, E. S. Denislamova, D. A. Shipilovskikh, R. R. Makhmudov, I. N. Chernov, N. M. Igidov

引用次数: 0

Abstract

A series of 2-amino-1-aryl-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylic acid derivatives was synthesized by the reaction of 4-arylamino-2-tert-butyl-5-oxo-2,5-dihydrofuran-2-yl acetates with cyanoacetic acid derivatives. Some of the synthesized compounds demonstrated antihypoxic effect thus proving themselves as promising candidates for more in-depth biological studies.

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2-氨基-1-芳基-5-（3,3-二甲基-2-氧基丁基）-4-氧基- 1h -4,5-二氢吡咯-3-羧酸衍生物的合成及抗氧活性研究

以4-芳基氨基-2-叔丁基-5-氧-2,5-二氢呋喃-2-乙酸酯为原料，合成了一系列2-氨基-1-芳基-5-（3,3-二甲基-2-氧丁基）-4-氧-4,5-二氢吡咯-3-羧酸衍生物。一些合成的化合物显示出抗缺氧作用，因此证明了它们是更深入的生物学研究的有希望的候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.