Synthesis and functionalization of P(O)CH2NH- and P(O)CH2NSi-containing amines

Abstract

Convenient syntheses of phosphorus-substituted amines containing P(O)CH₂NH and P(O)CH₂NSi moieties based on the reaction between N,N′,N″-trisubstituted hexahydro-1,3,5-triazines and trivalent phosphorus acid esters have been developed. Various functionalization reactions (2-carboxyethylation, 2-pyridylethylation, and acylation) of the NH and NSi units of the resulting synthons proceed under mild conditions and give new functionalized phosphorus-containing amines in high yields. The resulting compounds are of interest as promising biologically active substances, water-soluble polydentate ligands, and effective extractants.