Effect of coordination of 1,2,4-triazole moiety in Cu(ii) and Zn(ii) compounds with 2-{[(4H-1,2,4-triazol-4-yl)imino]methyl}phenol on their antimicrobial activity

Abstract

The reactions of copper(ii) and zinc(ii) salts with 2-{[(4H-1,2,4-triazol-4-yl)imino]-methyl}phenol (HL) were studied. The reaction of copper(ii) trifluoroacetate with HL in MeOH affords the mononuclear complex [CuL₂] (1). In the crystal, molecules 1 form a supramolecular layered structure through Cu⋯N contacts (2.74 Å). The reaction of zinc(ii) chloride with HL in the presence of Et₃N gives the 2D coordination polymer [ZnL₂]_n (2), whereas this reaction using a protonating agent (HCl) instead of the organic base produces the mononuclear complex [Zn(HL)₂Cl₂] (3). The photoluminescent properties of compounds HL, 2, and 3 were studied and their ¹H NMR spectra were measured. The electronic absorption spectra of all synthesized compounds in solution were recorded. The free ligand HL and compounds 1–3 were evaluated for antibacterial activity against E. coli and S. aureus strains, antifungal activity against the molds A. fumigatus, R. oryzae and the yeast fungi C. albicans, C. glabrata, and antiprotozoal activity against Colpoda steinii.