M. S. Shashin, A. A. Parfenov, A. B. Vyshtakalyuk, G. P. Belyaev, M. M. Shulaeva, I. V. Galyametdinova, A. F. Saifina, A. T. Gubaidullin, V. V. Zobov, V. E. Semenov
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引用次数: 0
Abstract
New pyrimidine derivatives were synthesized in order to identify structural moieties of the anti-burn drug Xymedon (1-(2-hydroxyethyl)-4,6-dimethyl-2-oxopyrimidine) responsible for its hepatoprotective properties and to expand the range of hepatoprotectors based on the pyrimidine platform. For the newly synthesized compounds, the structure—cytotoxicity relationship and cytoprotective properties (against the toxic effect of d-galactosamine) were determined using human cell lines in comparison with Xymedon. The modification of structural moieties of Xymedon was shown to increase the cytotoxicity of isostructural pyrimidines; nevertheless, a significant cytoprotective effect was revealed for some of them. The structure of one new pyrimidine, 4,6-diethyl-1-(2-hydroxyethyl)-2-oxopyrimidine, was confirmed by X-ray diffraction.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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