Rh(III)‐Catalyzed Regioselective [3+2]‐Annulation of Indoles with 1,3‐Enynes to Access 3H‐pyrrolo[1,2‐a]indol‐3‐ones

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC
Sanjeev Kumar , Pradeep Girase , Sayali Pradeep Jadhav , Bhargav Desai , Dr. Togati Naveen , Vinaykumar Kanchupalli
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引用次数: 0

Abstract

Herein, we present a novel and highly efficient strategy for the synthesis of synthetically valuable 3H‐pyrrolo[1,2‐a]indol‐3‐ones via a Rh(III)‐catalyzed regioselective [3+2] annulation strategy. The protocol ensures precise regioselective insertion of substituted 1,3‐enynes at the less sterically hindered site, while offering a broad substrate scope, excellent functional group compatibility, and mild reaction conditions. Moreover, the methodology is amenable to gram‐scale synthesis and demonstrates the successful application of terbinafine as a substrate within this transformation.
Rh(III)‐催化区域选择性[3+2]‐吲哚与1,3‐炔环化以获得3H‐吡咯[1,2‐a]吲哚‐3‐酮
在此,我们提出了一种新的和高效的策略,通过Rh(III)催化的区域选择性[3+2]环化策略来合成有合成价值的3H‐吡咯[1,2‐a]吲哚‐3‐酮。该方案确保在较少的空间阻碍位点上精确地区域选择性插入取代的1,3 -炔,同时提供广泛的底物范围,良好的官能团兼容性和温和的反应条件。此外,该方法适用于克尺度合成,并证明了特比萘芬作为底物在该转化中的成功应用。
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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