A review: Pyrazolo[1,5-a]pyrimidine as prominent fluorophores for chemosensory, optoelectronic and biological applications

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-05-15 DOI:10.1016/j.dyepig.2025.112896

Aluru Rammohan , P.C. Nagajyothi , Grigory V. Zyryanov , Pabba Durga Prasad , Jaesool Shim

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引用次数: 0

Abstract

Organic fluorophores are often used in advanced applications such as biological imaging, molecular sensors, optoelectronic dyes, and materials science. Pyrazolo[1,5-a]pyrimidines are pharmacologically important, fused N-heterocycles, as they have shown interesting clinical results against various human diseases. In addition, pyrazolo[1,5-a]pyrimidines are also pronounced for their intensive photophysical properties, suggesting their potential in material science applications. Accordingly, the current study focuses on the synthesis and functionalization of various pyrazolo[1,5-a]pyrimidines in the recent decade (2014–2025). Moreover, the discussion highlights the synthetic approaches for novel π-extended pyrazolo[1,5-a]pyrimidines and their fluorophore applications for chemosensory, optoelectronic and biological activities. As well, it is hoped that this review will act as a model for further research to develop efficient pyrazolo[1,5-a]pyrimidine-based fluorophores for biological and material science applications.

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吡唑啉[1,5- A]嘧啶在化学感觉、光电和生物等领域的应用综述

有机荧光团通常用于生物成像、分子传感器、光电染料和材料科学等高级应用。Pyrazolo[1,5-a]嘧啶是一种重要的融合n -杂环，在治疗多种人类疾病方面显示出有趣的临床结果。此外，pyrazolo[1,5-a]嘧啶也因其强烈的光物理性质而被宣布，这表明它们在材料科学中的应用潜力。因此，目前的研究重点是近十年（2014-2025）各种吡唑[1,5-a]嘧啶的合成和功能化。此外，重点讨论了新型π扩展吡唑[1,5-a]嘧啶的合成方法及其在化学感觉、光电和生物活性方面的荧光基团应用。同时，希望本综述将作为进一步研究开发高效的吡唑[1,5-a]嘧啶基荧光团的模型，用于生物和材料科学的应用。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.