Catalyst‐free One‐Pot Synthesis of Sulfonyl Fluorides from Triazenes via Multicomponent Reaction

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202500104

Truong Giang Luu , Hee‐Kwon Kim

引用次数: 0

Abstract

Sulfonyl fluorides are valuable structures in organic chemistry and drug discovery. In this study, a novel metal‐ and catalyst‐free method for synthesizing sulfonyl fluorides from aryltriazenes was developed. This reaction employed a one‐pot, multi‐component approach using aryltriazenes, DABSO, and NFSI in the presence of TFA. Using this method, a variety of sulfonyl fluorides was readily synthesized from aryltriazenes in high yields. This approach features simple reaction conditions, broad functional group tolerance, and ease of operation, proving an efficient and practical strategy for the preparation of sulfonyl fluorides.

查看原文本刊更多论文

无催化剂一锅法多组分反应合成磺酰氟的研究

磺酰氟化合物是有机化学和药物发现中有价值的结构。本研究提出了一种以芳基三嗪为原料合成磺酰氟化合物的新方法。该反应采用一锅、多组分的方法，在TFA存在下使用芳基三嗪、DABSO和NFSI。用这种方法，可以很容易地以芳基三嗪为原料合成多种磺酰氟化合物，收率高。该方法具有反应条件简单、官能团耐受性广、操作简便等特点，是制备磺酰氟化合物的一种高效实用的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.