Application of Desymmetrization: Synthesis of Atropisomeric Phosphite Esters via Thioether‐directed C−H Phosphorylation

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202500209

Linxi Yao , Chunmiao Shi , Jianming Pan , Peng Huang , Bin Liu

引用次数: 0

Abstract

Based on a desymmetrization strategy, a thioether‐directed C−H phosphorylation reaction of 1‐phenyl‐2‐alkylthionaphthalenes catalyzed by Pd (II) affords atropisomeric biaryl phosphite esters in moderate to good yields. The bifunctionalized by‐products were well inhibited. This newly developed methodology can be potentially applied to synthesize biaryl phosphite monomethyl esters containing alkylthio groups as bidentate anionic ligands.

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反对称技术的应用：硫醚定向C - H磷酸化合成亚磷酸酯

基于反对称策略，Pd （II）催化1 -苯基- 2 -烷基硫代萘的硫醚定向C - H磷酸化反应可获得中高收率的阿托品二芳基亚磷酸酯。双功能化副产物被很好地抑制。该方法可用于合成含烷基硫基双齿阴离子配体的亚磷酸酯二芳基单甲酯。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.