Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells

IF 4.4 2区 生物学 Q2 CELL BIOLOGY
Tingyu Chen, Yiming Xu, Fan Yang, Yanxin Pan, Ning Ji, Jing Li, Xin Zeng, Qianming Chen, Lu Jiang, Ying-Qiang Shen
{"title":"Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells","authors":"Tingyu Chen,&nbsp;Yiming Xu,&nbsp;Fan Yang,&nbsp;Yanxin Pan,&nbsp;Ning Ji,&nbsp;Jing Li,&nbsp;Xin Zeng,&nbsp;Qianming Chen,&nbsp;Lu Jiang,&nbsp;Ying-Qiang Shen","doi":"10.1016/j.cellsig.2025.111874","DOIUrl":null,"url":null,"abstract":"<div><div>Glutamine (Gln), a critical metabolic substrate, fuels the uncontrolled proliferation of cancer cells. Cancer-associated fibroblasts (CAFs), essential components of the tumor microenvironment, facilitate tumor progression by supplying Gln to cancer cells and driving drug resistance through metabolic reprogramming. This review highlights the key processes of Gln uptake, transport, and catabolism and explores the metabolic crosstalk between CAFs and cancer cells. It also examines the roles of major oncogenic regulators—c-Myc, mTORC, KRAS, p53, and HIF—in controlling Gln metabolism and shaping therapeutic resistance. Current pharmacological approaches targeting Gln metabolism, including enzyme inhibitors and transporter blockers, are discussed alongside emerging therapeutic strategies and ongoing clinical trials. Lastly, we underscore the importance of integrating advanced technologies like artificial intelligence and spatial omics to refine treatment targeting and develop more effective, personalized therapeutic interventions.</div></div>","PeriodicalId":9902,"journal":{"name":"Cellular signalling","volume":"133 ","pages":"Article 111874"},"PeriodicalIF":4.4000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular signalling","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S089865682500289X","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Glutamine (Gln), a critical metabolic substrate, fuels the uncontrolled proliferation of cancer cells. Cancer-associated fibroblasts (CAFs), essential components of the tumor microenvironment, facilitate tumor progression by supplying Gln to cancer cells and driving drug resistance through metabolic reprogramming. This review highlights the key processes of Gln uptake, transport, and catabolism and explores the metabolic crosstalk between CAFs and cancer cells. It also examines the roles of major oncogenic regulators—c-Myc, mTORC, KRAS, p53, and HIF—in controlling Gln metabolism and shaping therapeutic resistance. Current pharmacological approaches targeting Gln metabolism, including enzyme inhibitors and transporter blockers, are discussed alongside emerging therapeutic strategies and ongoing clinical trials. Lastly, we underscore the importance of integrating advanced technologies like artificial intelligence and spatial omics to refine treatment targeting and develop more effective, personalized therapeutic interventions.
肿瘤相关成纤维细胞与癌细胞间谷氨酰胺代谢的串扰
谷氨酰胺(Gln)是一种关键的代谢底物,促进癌细胞不受控制的增殖。癌症相关成纤维细胞(CAFs)是肿瘤微环境的重要组成部分,通过向癌细胞提供谷氨酰胺并通过代谢重编程驱动耐药,从而促进肿瘤进展。本文综述了谷氨酰胺摄取、转运和分解代谢的关键过程,并探讨了谷氨酰胺与癌细胞之间的代谢串扰。它还检查了主要的致癌调节因子- c- myc, mTORC, KRAS, p53和hif在控制Gln代谢和形成治疗抗性中的作用。目前针对谷氨酰胺代谢的药理学方法,包括酶抑制剂和转运蛋白阻滞剂,与新兴的治疗策略和正在进行的临床试验一起讨论。最后,我们强调整合人工智能和空间组学等先进技术的重要性,以完善治疗目标,并开发更有效,个性化的治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Cellular signalling
Cellular signalling 生物-细胞生物学
CiteScore
8.40
自引率
0.00%
发文量
250
审稿时长
27 days
期刊介绍: Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信