Measurement of lactate concentration using a minimally invasive needle with non-planer optical waveguides

IF 10.7 1区生物学 Q1 BIOPHYSICS

Biosensors and Bioelectronics Pub Date : 2025-05-08 DOI:10.1016/j.bios.2025.117557

Daigo Koiwa, Yoichi Haga, Noriko Tsuruoka

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引用次数: 0

Abstract

Traditional methods for sampling biological substance concentrations in blood are invasive and unsuitable for continuous monitoring. This paper presents a minimally invasive device equipped with optical waveguides on the surface of an acupuncture needle for measuring lactate concentration in subepidermal tissue, potentially in a continuous fashion. The device utilizes absorbance measurements, based on the correlation between absorbance and lactate concentration in tissue. The needle, with a diameter of 200 μm, exhibits good penetrability, particularly when coated with a biocompatible epoxy, which reduces insertion resistance. The experimental results demonstrate that the device can successfully measure the concentration of lactate solutions, with light intensity decreasing as the lactate concentration increases. However, challenges remain in optimizing the device to reduce optical losses and enhance measurement accuracy. Future work will focus on reducing optical loss, conducting animal experiments, and developing a miniaturized system for simultaneous measurement of multiple biological substances, aiming for practical applications in daily health monitoring.

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使用无刨光波导的微创针头测量乳酸浓度

传统的血液中生物物质浓度采样方法具有侵入性，不适合连续监测。本文提出了一种微创装置，在针针表面配备光波导，用于测量皮下组织中的乳酸浓度，可能以连续的方式。该装置利用吸光度测量，基于吸光度和组织中乳酸浓度之间的相关性。该针头的直径为200 μm，具有良好的穿透性，特别是在涂有生物相容性环氧树脂后，可以降低插入阻力。实验结果表明，该装置可以成功地测量乳酸溶液的浓度，且光强随乳酸浓度的增加而降低。然而，在优化器件以减少光损耗和提高测量精度方面仍然存在挑战。未来的工作将集中在减少光损失，进行动物实验，开发一种小型化的同时测量多种生物物质的系统，以期在日常健康监测中得到实际应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biosensors and Bioelectronics 工程技术-电化学

CiteScore

20.80

自引率

7.10%

发文量

1006

审稿时长

29 days

期刊介绍： Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.