Air pollution and adipokines: a systematic review

IF 4.2 2区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Atmospheric Environment Pub Date : 2025-05-02 DOI:10.1016/j.atmosenv.2025.121272

A.S. Espindola , B. Von Leiss , M.C.C. Kuschnir , I.M. Meyer , P.H. da Conceição , I.G.R. Giannini , R.J. Buralli , E. Faerstein

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引用次数: 0

Abstract

Background

Air pollution has been linked to negative obesity-related outcomes, and alterations in adipokine levels appear to mediate this relationship.

Objectives

This systematic review investigated the influence of outdoor air pollution on adipokine levels.

Methods

A systematic literature search of the PubMed, Embase, Web of Science, and Scopus databases for studies that assessed the relationship between air pollution and adipokine levels, published up to February 2023, was performed. Other databases included the Elton B. Stephens Company (EBSCO), a provider of research databases, and the Brazilian Library of Theses and Dissertations (BDTD).

Results

Eighty-two studies, published between 2006 and 2023, were included in this systematic review, among which 67.4 % were from the United States (34.9 %) and China (32.5 %), 39.8 % were panel studies, 36.1 % were cross-sectional and 21.7 % were cohort studies. Most (73.5 %) studies involved populations with multiple comorbidities, 59.0 % focused on evaluating particulate matter 2.5 (PM_2.5), and the majority (71.1 % [n = 59]) measured interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) (59.0 % [n = 49]), leptin (13.3 % [n = 11]), and adiponectin (10.8 % [n = 9]) levels. Covariates most frequently included in the models were age (75.9 %), body mass index (69.9 %), sex (63.9 %), smoking (42.2 %), education (39.8 %), and ambient temperature (38.6 %) and humidity (26.5 %). Of the included studies, 56.1 % found statistically significant, directly positive associations between outdoor exposure to air pollution and at least one of IL-6, TNF-α, adiponectin, leptin, and chemokine C-C motif ligand 2 levels.

Conclusion

Outdoor air pollution was found to be associated with increased adipokine levels in most studies.

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空气污染与脂肪因子：系统综述

空气污染与肥胖相关的负面结果有关，而脂肪因子水平的改变似乎介导了这种关系。目的探讨室外空气污染对脂肪因子水平的影响。方法系统检索PubMed、Embase、Web of Science和Scopus数据库，检索截至2023年2月发表的评估空气污染与脂肪因子水平之间关系的研究。其他数据库包括埃尔顿b斯蒂芬斯公司（EBSCO），一个研究数据库的提供者，和巴西论文图书馆（BDTD）。结果本系统评价共纳入2006 - 2023年间发表的72项研究，其中67.4%来自美国（34.9%）和中国（32.5%），39.8%为小组研究，36.1%为横断面研究，21.7%为队列研究。大多数（73.5%）的研究涉及有多种合并症的人群，59.0%的研究侧重于评估颗粒物2.5 (PM2.5)，大多数（71.1% [n = 59]）测量了白细胞介素(IL)-6、肿瘤坏死因子-α (TNF-α) （59.0% [n = 49]）、瘦素（13.3% [n = 11]）和脂联素（10.8% [n = 9]）水平。模型中最常见的协变量是年龄（75.9%）、体重指数（69.9%）、性别（63.9%）、吸烟（42.2%）、受教育程度（39.8%）、环境温度（38.6%）和湿度（26.5%）。在纳入的研究中，56.1%发现室外暴露于空气污染与至少一种IL-6、TNF-α、脂联素、瘦素和趋化因子C-C基序配体2水平之间有统计学意义的直接正相关。结论大多数研究发现室外空气污染与脂肪因子水平升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atmospheric Environment 环境科学-环境科学

CiteScore

9.40

自引率

8.00%

发文量

458

审稿时长

53 days

期刊介绍： Atmospheric Environment has an open access mirror journal Atmospheric Environment: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atmospheric Environment is the international journal for scientists in different disciplines related to atmospheric composition and its impacts. The journal publishes scientific articles with atmospheric relevance of emissions and depositions of gaseous and particulate compounds, chemical processes and physical effects in the atmosphere, as well as impacts of the changing atmospheric composition on human health, air quality, climate change, and ecosystems.