Sarcomatoid squamous cell carcinoma of the cervix: A case series and literature review

IF 1.5 4区医学 Q3 PATHOLOGY

Annals of Diagnostic Pathology Pub Date : 2025-05-13 DOI:10.1016/j.anndiagpath.2025.152501

Qiuyang Jing , Wenjuan Pu , Peng Guo , Xin Liao

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引用次数: 0

Abstract

Primary cervical sarcomatoid squamous cell carcinoma (SSCC), a rare biphasic malignancy with 29 documented cases, is characterized by co-existing malignant squamous epithelium and sarcomatoid spindle cells. Immunohistochemical co-expression of epithelial (PCK) and mesenchymal (vimentin) markers remains diagnostic. We analyzed 8 institutional cases (2006–2024) alongside literature reports. Patients (median age 46, range 28–72) predominantly presented with vaginal bleeding (7/8 cases), while one exhibited abdominal pain with discharge. HPV16 was detected in 2 cases. All tumors showed variable immunoreactivity for PCK, vimentin, p16, and ≥ 1 squamous marker (p63/p40/CK5/6). Treatment included chemotherapy (6/8) and radiotherapy (3/8). Follow-up (median 57.4 months, n = 7) revealed aggressive behavior: two stage IIIC patients developed supraclavicular/visceral metastases (alive with disease at 10–31 months), one stage IIIA patient died at 24 months, while others remained disease-free. Combined analysis with 29 published cases confirms SSCC's dual histologic presentation (biphasic/monophasic) and consistent epithelial-mesenchymal marker co-expression. These findings underscore SSCC's clinicopathologic heterogeneity and metastatic potential despite multimodal therapy.

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宫颈肉瘤样鳞状细胞癌：一个病例系列和文献复习

原发性宫颈肉瘤样鳞状细胞癌（SSCC）是一种罕见的双相恶性肿瘤，有29例文献记载，其特征是恶性鳞状上皮和肉瘤样梭形细胞共存。上皮（PCK）和间充质（vimentin）标记物的免疫组织化学共表达仍然具有诊断意义。我们分析了8个机构案例（2006-2024）和文献报道。患者（中位年龄46岁，范围28-72岁）主要表现为阴道出血（7/8例），而1例表现为腹痛并分泌物。2例检出HPV16。所有肿瘤对PCK、vimentin、p16和≥1个鳞状标志物（p63/p40/CK5/6）均表现出不同的免疫反应性。治疗包括化疗（6/8）和放疗（3/8）。随访（中位57.4个月，n = 7）显示了侵略性行为：2例IIIA期患者发生锁骨上/内脏转移（10-31个月时存活），1例IIIA期患者在24个月时死亡，而其他患者无疾病。对29例已发表病例的综合分析证实了SSCC的双重组织学表现（双相/单相）和一致的上皮-间充质标志物共表达。这些发现强调了SSCC的临床病理异质性和转移潜力，尽管多模式治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Diagnostic Pathology 医学-病理学

CiteScore

3.90

自引率

5.00%

发文量

149

审稿时长

26 days

期刊介绍： A peer-reviewed journal devoted to the publication of articles dealing with traditional morphologic studies using standard diagnostic techniques and stressing clinicopathological correlations and scientific observation of relevance to the daily practice of pathology. Special features include pathologic-radiologic correlations and pathologic-cytologic correlations.