Synthesis and characterization of hydroxyapatite-based nanocomposite coating with alginate biopolymer and MgO nanoparticles for enhanced antibacterial Properties

IF 2.9 Q1 MATERIALS SCIENCE, CERAMICS

Open Ceramics Pub Date : 2025-05-14 DOI:10.1016/j.oceram.2025.100799

Mohammad Moslem Imani , Parya Fatahi , Amin Golshah , Mohammad Salmani Mobarakeh , Mohsen Safaei

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Abstract

The objective of this study is to identify the ideal conditions for fabricating hydroxyapatite/alginate/MgO nanocomposite with potent antibacterial. The Taguchi approach was used to investigate the production of nanocomposites with the outstanding antibacterial properties. Three factors were studied at three levels, resulting in nine unique experiments. Characteristics such as surface appearance, chemical composition, elemental dispersion, thermal analysis and crystal structure were all evaluated. The findings showed that MgO nanoparticles and alginate biopolymer were evenly distributed throughout the hydroxyapatite matrix. The nanocomposite produced under experimental conditions 3 (0.03 M hydroxyapatite, 0.04 M alginate, and 0.08 M MgO) showed the strongest impact in inhibiting the growth of Streptococcus mutans at 1.84 Log₁₀ CFU/ml. This study illustrated that the fabricated nanocomposite had a stable performance under ideal conditions and the use of appropriate levels of components enhance the antibacterial activity of the fabricated nanocomposite.

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海藻酸盐生物聚合物和氧化镁纳米粒子羟基磷灰石基纳米复合涂层的合成与表征

本研究的目的是确定制备羟基磷灰石/海藻酸盐/氧化镁纳米复合材料的理想条件。采用田口法研究了具有优异抗菌性能的纳米复合材料的制备。三个因素在三个层面上被研究，产生了9个独特的实验。对其表面形貌、化学成分、元素色散、热分析和晶体结构等特征进行了评价。结果表明，MgO纳米粒子和海藻酸盐生物聚合物均匀分布在羟基磷灰石基质中。实验条件3 （0.03 M羟基磷灰石、0.04 M海藻酸盐和0.08 M MgO）制备的纳米复合材料在1.84 Log10 CFU/ml时对变形链球菌生长的抑制作用最强。本研究表明，制备的纳米复合材料在理想条件下具有稳定的性能，使用适当水平的组分可以增强制备的纳米复合材料的抗菌活性。

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