Thermodynamic analysis and separation kinetics of liquid-liquid extraction process in water-organic solvent-Quercetin system

IF 5.5 3区工程技术 Q1 ENGINEERING, CHEMICAL

Journal of the Taiwan Institute of Chemical Engineers Pub Date : 2025-05-17 DOI:10.1016/j.jtice.2025.106190

Mohd Aurif Shergujri, Gaurav Ashok Bhaduri

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引用次数: 0

Abstract

Background

Thermodynamic evaluation of Quercetin distribution in water and organic solvent system is important for the design of Quercetin separation process. Additionally, kinetic analysis of Quercetin distribution has an effect on its separation efficiency. These are useful in designing process for green separation of Quercetin involving aqueous extracts.

Methods

The liquid-liquid extraction process has been demonstrated with equilibrium data for water-organic solvent-Quercetin system. This is studied at three different temperatures i.e. 293, 303, and 313 K. The organic solvent mixture used was ethyl acetate-hexane (1:1 v/v). Kinetic studies of the purification process along with its optimisation was done using a stirred tank.

Significant Findings

The distribution coefficient of Quercetin was in the range of 9.5–0.78 and the separation factor was in the range of 281.7–22.7. The distribution coefficient and extraction efficiency was not affected with change in temperature. The degree of consistency of the equilibrium was evaluated using Othmer-Tobias equation. Additionally, the kinetic study showed that the mass transfer coefficient was a function of stirrer speed and volumetric ratio of aqueous to organic phase. The maximum mass transfer coefficient of 9.41 min^-1 was obtained for a stirrer speed of 600 rpm and ratio of V_aq/V_org of 2.

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水-有机溶剂-槲皮素体系液-液萃取过程热力学分析及分离动力学

槲皮素在水和有机溶剂体系中的分布热力学评价对槲皮素分离工艺的设计具有重要意义。此外，槲皮素分布的动力学分析对其分离效率也有影响。这对槲皮素水提物绿色分离工艺设计具有一定的指导意义。方法用平衡数据验证了水-有机溶剂-槲皮素体系的液-液萃取工艺。这在三种不同的温度下进行了研究，即293、303和313 K。使用的有机溶剂混合物为乙酸乙酯-己烷（1:1 v/v）。利用搅拌槽对纯化过程进行了动力学研究，并对其进行了优化。显著性发现槲皮素的分布系数在9.5 ~ 0.78之间，分离系数在281.7 ~ 22.7之间。分布系数和萃取效率不受温度变化的影响。利用Othmer-Tobias方程对平衡的一致性进行了评价。此外，动力学研究表明，传质系数是搅拌速度和水相与有机相体积比的函数。当搅拌转速为600 rpm， Vaq/Vorg为2时，传质系数最大，为9.41 min-1。

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来源期刊

Journal of the Taiwan Institute of Chemical Engineers 工程技术-工程：化工

CiteScore

9.10

自引率

14.00%

发文量

362

审稿时长

35 days

期刊介绍： Journal of the Taiwan Institute of Chemical Engineers (formerly known as Journal of the Chinese Institute of Chemical Engineers) publishes original works, from fundamental principles to practical applications, in the broad field of chemical engineering with special focus on three aspects: Chemical and Biomolecular Science and Technology, Energy and Environmental Science and Technology, and Materials Science and Technology. Authors should choose for their manuscript an appropriate aspect section and a few related classifications when submitting to the journal online.