Tryptophan-producing bacteria to mitigate osteoporosis and intestinal dysfunction

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-05-16 DOI:10.1016/j.bioactmat.2025.05.013

Bo Tian , Heng Wang , Yue Zhang , Jinmin Lv , Dongxiao Li , Chenmeng Zhou , Jialu Xu , Yichao Ni , Bingbing Wu , Mingchao Zhang , Huaxing Dai , Fang Xu , Jinyu Bai , Chao Wang , Xiaozhong Zhou

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Abstract

The relationship between gut microbiota and host health and disease is intricate, with microbiota-derived metabolites playing a crucial role in the gut-organ axis. In this study, we observe significantly decreased levels of microbial metabolites, particularly tryptophan derivatives in osteoporosis mice. Loss of tryptophan induced intestinal epithelial barrier dysfunction which compromised intestinal barrier integrity, leading to bone inflammatory responses and pathological osteoporosis. Through supplementation of tryptophan-producing bacteria, we effectively repair damaged intestinal barriers in colitis mice and mitigate bone loss, indicating the link between chronic colitis and osteoporosis. This approach offers a promising synthetic biology-based strategy to improve osteoporosis therapy by targeting gut tryptophan. This intervention also alleviates age-related osteoporosis in an aged mouse model, providing a potential therapeutic avenue for combating osteoporosis, a disease of growing concern in aging populations.

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色氨酸产生细菌减轻骨质疏松症和肠道功能障碍

肠道微生物群与宿主健康和疾病之间的关系是复杂的，微生物群衍生的代谢物在肠道器官轴中起着至关重要的作用。在这项研究中，我们观察到骨质疏松小鼠的微生物代谢物水平显著降低，特别是色氨酸衍生物。色氨酸缺失诱导肠上皮屏障功能障碍，损害肠屏障完整性，导致骨炎症反应和病理性骨质疏松症。通过补充色氨酸产生细菌，我们有效地修复了结肠炎小鼠受损的肠道屏障，减轻了骨质流失，表明慢性结肠炎与骨质疏松症之间存在联系。这种方法提供了一个有前途的合成生物学为基础的策略，以改善骨质疏松症的治疗靶向肠道色氨酸。这种干预也减轻了老年小鼠模型中与年龄相关的骨质疏松症，为对抗骨质疏松症提供了潜在的治疗途径，骨质疏松症是老年人日益关注的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.