Naringenin: A potential anticancer drug

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2025-05-15 DOI:10.1016/j.rechem.2025.102358

Yi Zhang, Haixin Ding, Xue Zhao, Yutong Li, Pengling Ge

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Abstract

Natural products, as vital bioactive components for human health maintenance, have garnered widespread attention for their medicinal value. Naringenin (NGE), a naturally occurring flavonoid abundant in citrus fruits, exhibits multiple pharmacological activities (including anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anticancer effects), despite its pharmacokinetic limitations such as poor oral bioavailability and rapid metabolism. Research has demonstrated that NGE exhibits broad-spectrum anticancer activity by targeting multiple molecular mechanisms, including induction of tumor cell apoptosis, modulation of cell cycle progression, and interference with key signaling pathways such as TGF-β1, PI3K/AKT/mTOR, and NF-κB. Recent advances in nanodrug delivery systems have effectively addressed these pharmacokinetic limitations while substantially improving NGE's anticancer efficacy. This review systematically summarizes current research progress on NGE's natural sources, anticancer mechanisms, and novel delivery strategies, with the aim of providing a scientific foundation for NGE-based anticancer drug development and clinical translation.

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柚皮素：一种潜在的抗癌药物

天然产物作为维持人体健康的重要生物活性成分，因其药用价值而受到广泛关注。柚皮素（NGE）是一种富含柑橘类水果的天然类黄酮，具有多种药理活性（包括抗炎、抗氧化、神经保护、肝保护和抗癌作用），尽管其药代动力学限制如口服生物利用度差和代谢快。研究表明，NGE通过靶向多种分子机制，包括诱导肿瘤细胞凋亡、调节细胞周期进程、干扰TGF-β1、PI3K/AKT/mTOR、NF-κB等关键信号通路，表现出广谱的抗癌活性。纳米药物传递系统的最新进展有效地解决了这些药代动力学限制，同时大大提高了NGE的抗癌功效。本文系统综述了NGE的天然来源、抗癌机制和新的给药策略等方面的研究进展，旨在为基于NGE的抗癌药物开发和临床转化提供科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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