Epigenetics: A link between toxicants and diseases

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-05-08 DOI:10.1016/j.isci.2025.112613

Anna Romanò , Christina Pagiatakis , Rosalba Gornati , Giovanni Bernardini , Roberto Papait

引用次数: 0

Abstract

Epigenetics is a complex network of molecular mechanisms, including DNA modifications, histone modifications, and non-coding RNA transcripts that influence gene transcription in heritable ways across cells. Over the last decades, epigenetic mechanisms have gained significant attention in the field of toxicology. Various research groups are investigating the epigenetic impact of toxicants due to their role in mediating the effects of environmental factors on cellular function, in complex diseases, and in explaining adverse effects on offspring. Here, we give an overview of these studies, exploring the intersection of epigenetics and toxicology and focusing on how not only environmental pollutants but also recreational substances, such as tobacco smoke and alcoholic beverages, can impact DNA and histone modifications.

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表观遗传学：毒素和疾病之间的联系

表观遗传学是一个复杂的分子机制网络，包括DNA修饰、组蛋白修饰和非编码RNA转录，它们以可遗传的方式影响细胞间的基因转录。在过去的几十年里，表观遗传机制在毒理学领域得到了极大的关注。各种研究小组正在调查毒物的表观遗传影响，因为它们在介导环境因素对细胞功能的影响、复杂疾病和解释对后代的不利影响方面发挥作用。在这里，我们对这些研究进行概述，探索表观遗传学和毒理学的交叉点，并重点关注环境污染物以及娱乐物质（如烟草烟雾和酒精饮料）如何影响DNA和组蛋白修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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