The association between pre-stroke physical activity and cerebral collateral circulation in acute ischaemic stroke

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neuroscience Pub Date : 2025-05-16 DOI:10.1016/j.jocn.2025.111314

Stanley Hughwa Hung , Sharon F Kramer , Emilio Werden , Jonathan Hall , Gagan Sharma , Hamed Asadi , Vincent Thijs , Bruce CV Campbell , Amy Brodtmann

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引用次数: 0

Abstract

Objectives

To investigate the association between pre-stroke physical activity and cerebral collateral circulation in acute ischaemic stroke survivors.

Methods

Using a cross-sectional design, we recruited ischaemic stroke survivors from two hospital acute stroke units and included participants with ICA and MCA M1/M2 segment occlusions. The Physical Activity Scale for the Elderly (PASE) was used to measure physical activity levels during the 7 days prior to stroke onset. Clinically acquired computed tomography perfusion (CTP) imaging was used to assess cerebral collateral circulation using the hypoperfusion intensity ratio (HIR) and visual grading with dynamic computed tomography angiography reconstructed from CTP images. Spearman’s correlation coefficient was used to examine the association between the PASE Total Score and HIR. Independent sample t-test was used to estimate the difference in HIR between those who reported engaging in pre-stroke leisure walking and those who did not.

Results

We included 29 participants (mean ± SD = 71.5 ± 12.5 years; 38 % female). No association was observed between the PASE Total Score and HIR. Participants who engaged in leisure walking (mean ± SD = 0.30 ± 0.21) had lower HIR compared to participants who did not (mean ± SD = 0.46 ± 0.14) (estimated mean difference = 0.16, 95 %CI = 0.01 to 0.31, p = 0.04).

Conclusions

This study provides preliminary evidence to suggest that pre-stroke leisure walking may an important activity type associated with cerebral collateral circulation. Larger studies are required to further investigate the relationship between pre-stroke physical activity and collateral circulation.

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急性缺血性脑卒中患者脑卒中前体力活动与脑侧支循环的关系

目的探讨急性缺血性脑卒中幸存者脑卒中前体力活动与脑侧支循环的关系。方法采用横断面设计，我们从两家医院急性卒中病房招募缺血性卒中幸存者，包括ICA和MCA M1/M2段闭塞的参与者。老年人体力活动量表（PASE）用于测量中风发作前7天的体力活动水平。临床获得性计算机断层扫描灌注（CTP）成像通过低灌注强度比（HIR）和动态计算机断层扫描血管成像视觉分级来评估脑侧支循环。采用Spearman相关系数检验PASE总分与HIR的相关性。采用独立样本t检验来估计卒中前休闲散步者和未参加者之间HIR的差异。结果纳入29例受试者(平均±SD = 71.5±12.5岁；女性占38%)。PASE总分与HIR无相关性。参加休闲散步的参与者（平均±SD = 0.30±0.21）的HIR低于没有参加的参与者（平均±SD = 0.46±0.14）（估计平均差异= 0.16,95% CI = 0.01至0.31,p = 0.04）。结论脑卒中前休闲步行可能是一种与脑侧支循环相关的重要活动类型。需要更大规模的研究来进一步调查中风前身体活动与侧支循环之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neuroscience 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

402

审稿时长

40 days

期刊介绍： This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.