Association of serum Klotho concentrations with abdominal obesity among middle-aged adults in the US: Evidence from NHANES 2011–2016

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2025-04-17 DOI:10.1016/j.nut.2025.112809

Yingyi Li , Xiaoqiang Liu , Xiaodong Zhu, Chanchan Lin, Xinqi Chen, Yingxuan Huang, Zicheng Huang

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引用次数: 0

Abstract

Objectives

The role of Klotho in metabolic processes and aging-related conditions is well-established. However, the link between Klotho and visceral adipose tissue (VAT) remains understudied. The aim of this study was to explore the relationship between Klotho levels and both VAT area and abdominal obesity.

Methods

A cross-sectional analysis encompassing 3316 middle-aged individuals was conducted using data from the National Health and Nutrition Examination Survey (NHANES 2011 to 2016). Dual-energy X-ray absorptiometry (DXA) was utilized to assess the VAT region, while abdominal obesity was defined by a VAT area exceeding 100 cm². The relationship between Klotho and VAT area was evaluated using multiple linear regression, and the association between Klotho and abdominal obesity was assessed using multivariate logistic regression. To assess linearity and explore the dose-response curve, restricted cubic splines were applied.

Results

Higher Klotho levels were associated with a lower VAT area (β −5.57, 95% CI = −9.83 - −1.30; P = 0.011) and a reduced incidence of abdominal obesity (OR 0.57, 95% CI = 0.42–0.78; P < 0.001), after adjusting for all model variables. Furthermore, multivariate smooth splines analysis revealed a nonlinear, L-shaped relationship between Klotho and both VAT area and abdominal obesity. A significant negative association was observed, with the curves leveling off as Klotho levels increased beyond 1.155 ng/mL. An L-shaped nonlinear relationship between Klotho and the VAT area indicated a saturation effect.

Conclusions

These findings warrant attention and suggest that further investigation into the association between serum Klotho and abdominal obesity is necessary.

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美国中年人血清Klotho浓度与腹部肥胖的关系：来自NHANES 2011-2016的证据

目的明确Klotho在代谢过程和衰老相关疾病中的作用。然而，Klotho与内脏脂肪组织（VAT）之间的联系仍未得到充分研究。本研究的目的是探讨Klotho水平与VAT面积和腹部肥胖之间的关系。方法采用全国健康与营养检查调查（NHANES 2011 - 2016）的数据，对3316名中年人进行横断面分析。双能x线吸收仪（DXA）用于评估VAT区域，而腹部肥胖的定义是VAT面积超过100 cm²。采用多元线性回归评估Klotho与VAT面积之间的关系，采用多元逻辑回归评估Klotho与腹部肥胖之间的关系。为了评估线性和探索剂量-响应曲线，采用了限制三次样条。结果较高的Klotho水平与较低的增值率相关(β - 5.57, 95% CI = - 9.83 - - 1.30；P = 0.011)和腹部肥胖发生率降低(OR 0.57, 95% CI = 0.42-0.78；P & lt;0.001)，在调整了所有模型变量后。此外，多变量光滑样条分析揭示了Klotho与VAT面积和腹部肥胖之间的非线性l型关系。观察到显著的负相关，随着Klotho水平超过1.155 ng/mL，曲线趋于平缓。Klotho与VAT面积呈l形非线性关系，表明存在饱和效应。结论这些发现值得关注，并提示有必要进一步研究血清Klotho与腹部肥胖的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.