Amifostine-loaded Prussian blue nanoparticles for simultaneous efficient radioprotection and deep decorporation of radiocesium

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-05-13 DOI:10.1016/j.colsurfb.2025.114788

Boyan Wang, Yuchen Liu, Chengqi Li, Meiyun Xu, Daoben Hua

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引用次数: 0

Abstract

Radiocesium is highly water-soluble and easily accumulates in agricultural products and seafood. Ingestion of radiocesium results in internal irradiation, significantly increasing the risk of tissue and organ damage as well as carcinogenesis. In this paper, we develop a strategy for simultaneous radioprotection and decorporation of radiocesium by amifostine-loaded Prussian blue (Am@PB) nanoparticles. The nanoparticles are prepared through chemical coordination between amine/phosphate groups of amifostine and Fe (II)/Fe (III) sites of Prussian blue (PB). Am@PB nanoparticles mitigate radiation-induced damage to peripheral blood cells and organs, improving the survival rate of irradiated mice. This is due to the synergistic effects of the nano-enzymatic activity of PB component and the high reducibility of sulfhydryl groups generated through amifostine hydrolysis by alkaline phosphatase. Furthermore, the deep excretion of cesium is achieved via feces along the metabolic pathway of Am@PB, leading to an enhanced decorporation efficiency of over 50 % compared to orally administered commercial PB. This work provides a design strategy for efficient radioprotective decorporation agents with potential applications in the treatment of internal radiocesium contamination.

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氨磷汀负载的普鲁士蓝纳米粒子同时有效的辐射防护和放射性铯的深度降解

放射性铯是高度水溶性的，很容易在农产品和海鲜中积累。摄入放射性铯会导致体内照射，显著增加组织和器官损伤以及致癌的风险。在本文中，我们开发了一种策略，同时辐射防护和放射性铯的氨磷汀负载普鲁士蓝（Am@PB）纳米颗粒。该纳米颗粒是通过氨磷汀的胺/磷酸基团与普鲁士蓝（PB）的铁(II)/铁（III）位点之间的化学配位制备的。Am@PB纳米颗粒减轻辐射对外周血细胞和器官的损伤，提高受辐射小鼠的存活率。这是由于PB组分的纳米酶活性的协同作用和碱性磷酸酶水解氨磷氨酸产生的巯基的高还原性。此外，铯的深层排泄是通过粪便沿着Am@PB代谢途径实现的，与口服商业PB相比，其去除效率提高了50% %以上。本工作提供了一种有效的放射性防护脱孔剂的设计策略，在处理内部放射性铯污染方面具有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.