Synthetic studies towards (−)-plicatic acid: A Ni-catalyzed reductive cyclization strategy for the construction of its aryltetralin framework

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-05-14 DOI:10.1016/j.tet.2025.134724

Xiao-Wei Cong , Yu Peng

引用次数: 0

Abstract

Plicatic acid is an aryltetralin lignan that can cause inflammatory and allergic reactions. A new construction of its carbon framework has been achieved herein. This synthetic strategy features the following key steps: asymmetric conjugate addition for installation of one aryl fragment, and an intramolecular Ni-catalyzed reductive cyclization to build the desired aryltetralin core structure.

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（−）-塑胶酸的合成研究：镍催化还原环化策略构建芳基四氢萘骨架

塑酸是一种芳香烃木脂素，可引起炎症和过敏反应。本文实现了一种新的碳骨架结构。该合成策略具有以下关键步骤：不对称共轭加成以安装一个芳基片段，以及分子内ni催化的还原环化以构建所需的芳基四烯核心结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.