Targeted Protein Degradation: From Basic Science to Therapeutic Applications

IF 3.5 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Biology Pub Date : 2025-04-18 DOI:10.1021/acschembio.5c0006710.1021/acschembio.5c00067

Rongfeng Zhu*, Xiaoyu Tang* and Heng Zhang*,

引用次数: 0

Abstract

Targeted protein degradation (TPD) is a groundbreaking approach in molecular therapeutics, enabling the selective elimination of specific proteins by leveraging the cell’s own degradation machinery. In November 2024, the SMART Symposium titled “Targeted Protein Degradation: from basic science to therapeutic applications” offered a comprehensive communication on the cutting-edge chemical strategies and emerging clinical applications in this rapidly advancing field.

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靶向蛋白降解：从基础科学到治疗应用

靶向蛋白降解（Targeted protein degradation， TPD）是分子治疗领域的一种突破性方法，它通过利用细胞自身的降解机制，实现对特定蛋白的选择性清除。2024年11月，题为“靶向蛋白质降解：从基础科学到治疗应用”的SMART研讨会就这一快速发展领域的前沿化学策略和新兴临床应用进行了全面交流。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Chemical Biology 生物-生化与分子生物学

CiteScore

7.50

自引率

5.00%

发文量

353

审稿时长

3.3 months

期刊介绍： ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.