Path analysis of trace elements and physiological and biochemical indices associated to mild cognitive impairment in elderly Chinese

IF 7.6 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2025-05-16 DOI:10.1016/j.envpol.2025.126470

Peiyi Liu , Haiyan Huang , Qimei Zhou , Ying Zhi , Jiahui Wang , Ying Fu , Erwei Gao , Xiaohu Ren , Xiao Chen , Xinfeng Huang , Jianjun Liu , Xifei Yang

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Abstract

The intricate relationships between cognitive function and a broad spectrum of trace elements and physiological and biochemical indices remain unclear. This study aimed to employ a path analysis model to investigate the effects of multiple trace elements and physiological and biochemical factors on mild cognitive impairment (MCI) among elderly Chinese. A total of 5768 residents aged 60 years and older were recruited in Shenzhen, China. Cognitive function was evaluated using the Mini-Mental State Examination and the Mini-Cognitive Assessment. Concentrations of 18 trace elements in urine were quantified with adjustments for urinary creatinine levels. Physiological and biochemical indices were acquired at community health centers. Based on the multiple logistic regression analysis, only selenium exhibited significant negative correlations with MCI (p-trend = 0.035). Serum albumin (ALB), triglyceride (TG), bone mineral density (BMD) and mitochondrial DNA copy number (mtDNAcn) exhibited negative correlations with high risk of MCI, whereas serum uric acid (SUA) and fasting blood glucose (FBG) were positively correlated with a higher risk of MCI. In addition, the path analysis model demonstrated that cobalt had direct effect on cognitive function, whereas iron, manganese, selenium, zinc, and copper affected it indirectly. Furthermore, the model identified that mtDNAcn directly affected cognitive function, while the other four physiological and biochemical indicators, including ALB, TG, BMD and SUA, had both direct and interactive indirect effects on it. Trace elements and physiological and biochemical indices exerted both direct and indirect effects on MCI. Specifically, trace elements might indirectly affect cognitive function through physiological and biochemical indices, which interact with each other.

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中国老年人轻度认知障碍的微量元素与生理生化指标的通径分析

认知功能与广泛的微量元素和生理生化指标之间的复杂关系尚不清楚。本研究旨在采用通径分析模型探讨多种微量元素及生理生化因素对中国老年人轻度认知障碍（MCI）的影响。在中国深圳共招募了5768名60岁及以上的居民。认知功能评估采用迷你精神状态检查和迷你认知评估。通过调整尿肌酐水平，定量测定了18种微量元素在尿液中的浓度。在社区卫生中心采集生理生化指标。多元logistic回归分析显示，只有硒与MCI呈显著负相关（p-trend = 0.035）。血清白蛋白（ALB）、甘油三酯（TG）、骨密度（BMD）和线粒体DNA拷贝数（mtDNAcn）与MCI高风险呈负相关，而血清尿酸（SUA）和空腹血糖（FBG）与MCI高风险呈正相关。此外，通径分析模型表明，钴对认知功能有直接影响，而铁、锰、硒、锌和铜对认知功能有间接影响。此外，该模型发现mtDNAcn直接影响认知功能，而其他四个生理生化指标，包括ALB、TG、BMD和SUA，对其既有直接作用，也有相互作用的间接作用。微量元素和生理生化指标对MCI有直接和间接影响。具体来说，微量元素可能通过生理生化指标间接影响认知功能，这些指标之间相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.