Enhanced ferroptosis in triple-negative cancer cells achieved by a type-I cell membrane-targeted tetrabenzophenazine photosensitizer

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2025-05-15 DOI:10.1016/j.snb.2025.137978

Zhuo-Liang Zhou , Xiao Zhang , Ming-Hao Hu

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引用次数: 0

Abstract

Triggering ferroptosis emerges as a promising anticancer therapeutic strategy. Photodynamic therapy based on cell membrane-targeted agents presents a chance to facilitate ferroptosis. However, there have been limited reports on this topic. In this study, we introduced a type-I cell membrane-targeted photosensitizer capable of inducing ferroptosis (FQ2). The study demonstrated that FQ2 was located on cell membrane, and the FQ2-mediated PDT could promote ferroptosis, which was attributed to GSH depletion, NADH oxidation, and GPX4 downregulation, ultimately causing lipid peroxidation (LPO) accumulation. Moreover, FQ2 was capable to induce apoptosis, as well as immunogenic cell death (ICD) upon irradiation. Finally, FQ2 exhibited good anticancer activity in vivo using a 4T1 tumor-bearing mouse model. Overall, this work provided an example for the development of cell membrane-targeted ferroptosis inducers.

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通过i型细胞膜靶向四苯并吩嗪光敏剂实现三阴性癌细胞的铁下垂增强

触发铁下垂是一种很有前途的抗癌治疗策略。基于细胞膜靶向药物的光动力疗法提供了促进铁下垂的机会。然而，关于这一主题的报道有限。在这项研究中，我们引入了一种能够诱导铁下垂（FQ2）的i型细胞膜靶向光敏剂。本研究表明，FQ2位于细胞膜上，FQ2介导的PDT可促进铁凋亡，其机制与GSH耗竭、NADH氧化、GPX4下调有关，最终导致脂质过氧化（LPO）积累。此外，FQ2能够在照射后诱导细胞凋亡和免疫原性细胞死亡（ICD）。最后，在4T1荷瘤小鼠模型中，FQ2在体内表现出良好的抗癌活性。总的来说，这项工作为开发细胞膜靶向的铁下垂诱导剂提供了一个例子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.