In memoriam: Harry Dalton (17th December 1958-19th March 2024)

Abstract

Hepatitis E virus (HEV) infection is a hepatotropic infection of global importance, an international scourge, and a cause of significant death and morbidity. It causes endemic outbreaks typically, and particularly in Asia, which are associated with faecal-oral/water-borne transmission and a high mortality in vulnerable groups, including pregnant women. In Western countries, sporadic HEV infections cause severe jaundice, liver decompensation and inflammation, typically in older men. HEV has also been shown to cause persistent infection in immune compromised people leading to liver fibrosis and cirrhosis, and severe neurological disease. Harry Dalton, a UK-based clinician scientist dedicated his academic career to the study of HEV infection and is internationally renowned for his discoveries on the pathogenesis of HEV. His career path was both unconventional and remarkable and he touched many of us with his inspirational work and determination. In this memoriam we aim to highlight his extraordinary contributions, drive, and dedication to hepatology, that may serve as an inspiration to others. Harry constantly challenged the existing “dogmas” opening our eyes to new possibilities and theories – it was this open mindedness, along with his ability to enthuse others, establishing life-long collaborations, that enabled his discoveries.